荆杏止咳颗粒治疗小儿外感咳嗽风寒化热证的临床研究

发布时间：2018-05-14 11:36

本文选题：荆杏止咳颗粒 + 小儿外感咳嗽　；参考：《湖北中医药大学》2012年硕士论文

【摘要】：目的：本课题旨在研究荆杏止咳颗粒治疗小儿外感咳嗽风寒化热证的有效性与安全性。方法：本试验病例均来自于2009年10月到2010年6月于湖北省中医院门诊就诊的患儿,按照西医急性支气管炎和中医外感咳嗽风寒化热证的诊断标准从中筛选48例,按完全随机的方法以1：1：1的比例分为高剂量组、中剂量组、极低剂量组,经统计分析各组间病例在年龄、性别、病程方面无显著差异,具有可比性。再分别予高、中、极低剂量荆杏止咳颗粒口服,服用方法为3岁以上,每次1袋；6岁-14岁,每次2袋,温开水冲服,一日三次,5天为一个疗程。疗程结束后比较三组在疾病疗效、主要症候积分、症候总积分、服药后起效时间的差异性,并通过观察入选病例治疗前后血常规、尿常规、粪常规及心电图、肝、肾功能及出现的不良反应以评价其安全性。结果： 1.治疗后有效率比较：高、中剂量组总有效率93.75%,极低剂量组总有效率31.25%,高、中剂量组与极低剂量组比较均有显著差异(P0.05)。中剂量组与高剂量组总有效率比较,P0.05,差异无统计学意义；高剂量组的临床痊愈率优于中剂量组,但差异不具有统计学意义(P0.05)。 2.主要症候积分比较：主要症候积分(咳嗽、肺部听诊、咯痰)治疗前组间比较,高、中、极低剂量组比较无显著性差异(P0.05),具有可比性。治疗前后比较,高、中剂量组均有显著性差异(P0.05),治疗后明显优于治疗前,极低剂量组治疗前后比较无显著性差异(P0.05)。治疗后三组组间比较,高、中剂量组与极低剂量组比较均具有显著差异(P0.05)；高剂量组与中剂量组比较P0.05,差异不具有统计学意义 3.症候总积分比较：症候总积分治疗前高、中、极低剂量组比较无显著性差异(P0.05),具有可比性。高、中、极低剂量组组内治疗前后比较有显著性差异(P0.05),治疗后明显优于治疗前。治疗后三组组间比较,高、中剂量组与极低剂量组比较均具有显著差异(P0.05)；高剂量组与中剂量组比较差异不具有统计学意义(P0.05)。治疗前后总积分差值组间比较,高、中剂量组与极低剂量组比较差异均具有显著差异(P0.05),高、中剂量组间比较差异无统计学意义(P0.05)。 4.三组起效时间比较：高、中、极低剂量组三组在服药后起效时间的差异有统计学意义,高剂量组优于中剂量组,中剂量组优于极低剂量组。 5.治疗前后三组血、尿、粪常规、心电图、肝功能、肾功能均未出现异常,未发现不良反应的情况。结论：极低剂量荆杏止咳颗粒治疗小儿外感咳嗽效果欠佳。高、中剂量荆杏止咳颗粒治疗小儿外感咳嗽效果确切,疗效满意；二者在疾病总有效率、改善症候方面无显著差异,但起效时间高剂量组优于中剂量组,安全可靠,具有广泛的应用前景,值得进一步深入研究推广
[Abstract]:Objective : To study the efficacy and safety of Jingxing Zhike Granule in treating infantile cough due to cough .

Methods : From October 2009 to June 2010 in Hubei Province , 48 cases were screened according to the diagnostic criteria of acute bronchitis and cough wind - cold syndrome in Hubei Province .
After treatment , three groups were divided into three groups : treatment effect , main symptom score , total score of syndrome , time difference after taking medicine , and the safety was evaluated by observing the routine , routine , routine and electrocardiogram , liver , renal function and adverse reaction of the patients before and after the treatment .

Results :

1 . After treatment , the total effective rate was 93.75 % , the total effective rate of the low - dose group was 31.25 % , the total effective rate of the low - dose group was 31.25 % , and the total effective rate in the middle - dose group was significantly higher than that in the low - dose group ( P0.05 ) .
The clinical cure rate of the high - dose group was better than that in the middle - dose group , but the difference was not statistically significant ( P0.05 ) .

2 . There was no significant difference between the two groups ( P0.05 ) . There was no significant difference between the two groups ( P0.05 ) .
There was no significant difference between the high dose group and the middle dose group ( P0.05 ) .

3 . There was no significant difference between the two groups ( P0.05 ) . There was a significant difference between the two groups ( P0.05 ) .
There was no significant difference between the high and middle dose groups ( P0.05 ) . There was no significant difference between the two groups ( P0.05 ) .

4 . The effect time of three groups was higher than that in the middle and low dose groups . The high dose group was superior to the middle dose group , and the middle dose group was superior to the extremely low dose group .

5 . Before and after treatment , three groups of blood , urine , feces routine , electrocardiogram , liver function , renal function were not abnormal , no adverse reaction was found .

Conclusion : The effect of low dose of Jingxing Zhike Granule on cough in children is not good . The effect of high and medium dose of Jingxing Zhike Granule on cough in children is exact and the curative effect is satisfactory .
Both have no significant difference in the total effective rate and the improvement symptoms of the disease , but the effective time high - dose group is superior to the middle - dose group , is safe and reliable , has wide application prospect , and is worthy of further research and popularization .

【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272

【参考文献】