不同剂量布地奈德混悬液雾化吸入治疗小儿哮喘急性发作的疗效及安全性对比

发布时间：2018-05-14 20:50

本文选题：临床疗效 + 小儿哮喘　；参考：《齐齐哈尔医学院学报》2015年04期

【摘要】：目的探析小儿哮喘急性发作进行不同剂量布地奈德混悬液雾化吸入治疗的临床效果及安全性对比。方法入选我院2013年1月至2014年1月哮喘急性发作患儿100例,按治疗方式的不同分为观察组、对照组,每组50例;所有患者均进行激素、氨茶碱、抗感染、止咳化痰、氧疗等常规治疗;观察组在常规治疗基础上予以1.0 mg/次布地奈德混悬液治疗,对照组在常规治疗基础上予以0.5 mg/次布地奈德混悬液治疗,治疗24 h、72 h后比较两组临床症状体征持续时间及不良反应。结果两组患者治疗24 h、72 h后临床表现评分均显著下降,观察组治疗后24h、72h临床表现评分显著低于对照组,差异有统计学意义(P0.05);观察组、对照组的不良反应发生率分别为6.0%、4.0%,差异无统计学意义(P0.05)。结论小儿哮喘患者进行高剂量布地奈德混悬液雾化治疗能有效控制急性发作,临床疗效确切,安全可靠,值得临床推广。
[Abstract]:Objective to compare the efficacy and safety of different doses of budesonide suspension aerosol inhalation in the treatment of acute asthma in children. Methods from January 2013 to January 2014, 100 children with acute asthma attack were divided into observation group (n = 50) and control group (n = 50). All patients were treated with hormones, aminophylline, anti-infection, cough and phlegm. The observation group was treated with 1.0 mg/ budesonide suspension and the control group was treated with 0.5 mg/ budesonide suspension on the basis of routine therapy. After treatment for 24 h and 72 h, the duration of clinical symptoms and signs and adverse reactions were compared between the two groups. Results the clinical symptom scores of the two groups decreased significantly after treatment for 24 hours and 72 hours after treatment, and the clinical symptoms scores in the observation group were significantly lower than those in the control group at 24 hours and 72 hours after treatment, the difference was statistically significant (P 0.05), while that in the observation group was significantly lower than that in the control group. The incidences of adverse reactions in the control group were 6.0 and 4.0, respectively. The difference was not statistically significant (P 0.05). Conclusion High dose budesonide suspension atomization can effectively control acute attack in children with asthma.
【作者单位】：广东省潮州市中心医院儿科;
【分类号】：R725.6

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