儿童呼吸道肺炎链球菌感染的耐药性及危险因素分析

发布时间：2018-05-14 19:38

本文选题：儿童 + 呼吸道感染　；参考：《中华医院感染学杂志》2017年07期

【摘要】：目的探讨儿童呼吸道肺炎链球菌感染的相关危险因素及耐药性,对临床抗菌药物的使用提供参考依据。方法收集医院2013年1月-2015年12月收治的呼吸道感染患儿4 424例,对其痰液标本进行培养并检测肺炎链球菌的感染情况,对不同年龄段、不同时间感染情况进行分析,使用VITEK-2检测肺炎链球菌对常用12种抗菌药物的耐药性。结果 4 424例患儿共检出肺炎链球菌感染379例,检出率为8.57%;年龄2岁患儿检出率为12.43%,明显高于年龄≥2岁的患儿(P0.05),每年的春季3月、4月和5月份以及冬季11月、12月和1月,肺炎链球菌的检出率较高;对万古霉素、左氧氟沙星和阿莫西林的敏感率均为100.00%,对头孢呋辛、头孢克洛及氯霉素的敏感率≥81.00%,但是对红霉素、磺胺甲VA唑、四环素以及克林霉素的耐药率均85.00%。结论儿童呼吸道肺炎链球菌感染检出率随时间变化,不同年龄段检出率有所差异,对不同的抗菌药物有不同程度的耐药性。
[Abstract]:Objective to investigate the risk factors and drug resistance of Streptococcus pneumoniae infection in children, and to provide reference for clinical use of antimicrobial agents. Methods 4,424 children with respiratory tract infection were collected from January 2013 to December 2015. The sputum samples were cultured and the infection status of Streptococcus pneumoniae was detected. VITEK-2 was used to detect the resistance of Streptococcus pneumoniae to 12 commonly used antimicrobial agents. Results A total of 379 cases of Streptococcus pneumoniae infection were detected in 4 424 cases, the detectable rate was 8.57 and 12.433.The detection rate was significantly higher than that of children aged more than 2 years (P 0.05). Every spring, March, April and May, and winter, November, December and January, respectively, were detected in children with Streptococcus pneumoniae. The sensitivity of Streptococcus pneumoniae to vancomycin, levofloxacin and amoxicillin was 100.00. the sensitivity rate to cefuroxime, cefaclor and chloramphenicol was more than 81.00, but to erythromycin, sulfamethoxazole, and sulfamethoxazole. The resistance rates of tetracycline and clindamycin were 85.00%. Conclusion the detection rate of Streptococcus pneumoniae infection varies with time in children, and the detection rate of Streptococcus pneumoniae is different in different age groups, and has different drug resistance to different antimicrobial agents.
【作者单位】：海南省人民医院龙华儿科;
【基金】：海南省自然科学基金资助项目(814399)
【分类号】：R725.6

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