感染性肺炎患儿血清及灌洗液中肺表面活性蛋白及炎性介质水平的变化研究

发布时间：2018-05-15 20:39

本文选题：新生儿 + 感染性肺炎　；参考：《中华医院感染学杂志》2017年03期

【摘要】：目的探讨新生儿感染性肺炎血清及灌洗液中肺表面活性蛋白及炎性介质水平的变化情况,为临床治疗提供参考依据。方法选取2014年5月-2015年12月医院收治160例感染性肺炎新生儿患儿为研究组,另选非感染性疾病新生儿120例为对照组,对两组新生儿患儿血清和灌洗液中肺表面活性蛋白A(SP-A)、肺表面活性蛋白B(SP-B)和肺表面活性蛋白C(SP-C)以及炎性介质肿瘤坏死因子α(TNF-α)、白细胞介素4(IL-4)和白细胞介素6(IL-6)的变化进行比较分析。结果与对照组相比,研究组新生儿患儿血清肺表面活性蛋白SP-A和SP-B水平均明显降低,且灌洗液SP-A、SP-B和SP-C水平均明显降低,血清炎性介质TNF-α水平明显升高,IL-4和IL-6水平均明显降低,而灌洗液炎性介质TNF-α水平升高,IL-6水平均明显降低,差异均有统计学意义(P0.05);与治疗前相比,研究组新生儿患儿治疗后血清SP-A和SP-B水平均明显提高,且灌洗液SP-A、SP-B和SP-C水平均明显提高,血清炎性介质TNF-α水平降低,IL-4和IL-6水平均明显提高,而灌洗液炎性介质TNF-α水平降低,IL-6水平均明显提高,与对照组相比,差异均有统计学意义(P0.05)。结论血清和灌洗液肺表面活性蛋白及炎性介质水平的检测对于新生儿感染性肺炎患儿临床治疗方案的选择具有一定的辅助作用。
[Abstract]:Objective to investigate the changes of pulmonary surfactant protein and inflammatory mediators in serum and lavage fluid of neonatal infectious pneumonia and to provide reference for clinical treatment. Methods from May 2014 to December 2015, 160 neonates with infectious pneumonia were selected as study group and 120 newborns with non-infectious diseases as control group. The changes of pulmonary surfactant protein (SP-An), pulmonary surfactant protein (BnSP-B), pulmonary surfactant protein (CnSP-C), inflammatory mediators tumor necrosis factor 伪 -TNF- 伪, interleukin-4 (IL-4) and interleukin-6 (IL-6) in serum and lavage fluid of newborns were compared and analyzed between the two groups. Results compared with the control group, the levels of serum pulmonary surfactant protein (SP-A) and pulmonary surfactant (SP-B) in the study group were significantly lower than those in the control group, and the levels of SP-An SP-B and SP-C in the lavage fluid were significantly lower than those in the control group. The levels of serum inflammatory mediators TNF- 伪 were significantly increased and the levels of IL-4 and IL-6 were significantly decreased. However, the level of TNF- 伪 in lavage fluid increased significantly and the level of IL-6 decreased significantly (P 0.05). Compared with before treatment, the levels of serum SP-A and SP-B in the study group were significantly higher than those before treatment. The levels of SP-An SP-B and SP-C in the lavage fluid were significantly increased, the levels of serum inflammatory mediators TNF- 伪 and IL-4 and IL-6 were significantly increased, while the levels of TNF- 伪 in the lavage fluid were significantly higher than those in the control group (P 0.05). Conclusion the detection of pulmonary surfactant and inflammatory mediators in serum and lavage fluid may be helpful to the choice of clinical treatment for neonatal infectious pneumonia.
【作者单位】：河南省中医院儿科;
【基金】：河南省卫生厅科技创新人才项目(20140051)
【分类号】：R725.6

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