丙种球蛋白联合阿司匹林肠溶片治疗川崎病的临床研究

发布时间：2018-05-15 22:30

本文选题：丙种球蛋白 + 阿司匹林肠溶片　；参考：《中国临床药理学杂志》2017年23期

【摘要】：目的比较不同用法的丙种球蛋白联合阿司匹林肠溶片治疗川崎病的临床疗效及安全性。方法将90例川崎病患儿随机分为对照组45例和试验组45例。对照组予以1 g·kg~(-1)丙种球蛋白,静脉注射,连续2 d+40 mg·kg~(-1)阿司匹林肠溶片,qd,口服,持续1个月;试验组予以2 g·kg~(-1)丙种球蛋白,一次性静脉注射+40 mg·kg~(-1)阿司匹林肠溶片,qd,口服,持续1个月。比较2组患儿的临床疗效、白细胞介素-6(IL-6)、IL-8、超敏C-反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α),以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.56%(43例/45例))和84.44%(38例/45例),差异有统计学意义(P0.05)。治疗后1个月,试验组和对照组的IL-6分别为(6.18±2.10)和(9.10±3.19)pg·m L~(-1),IL-8分别为(5.17±1.01)和(10.27±2.15)pg·m L~(-1),hs-CRP分别为(2.61±1.04)和(5.27±0.97)mg·L~(-1),TNF-α分别为(13.77±0.86)和(16.52±1.13)ng·L~(-1),差异均有统计学意义(均P0.05)。试验组的药物不良反应主要有恶心和头痛,对照组的药物不良反应主要有恶心、头痛和寒战。试验组和对照组的总药物不良反应发生率分别为17.78%和13.33%,差异无统计学意义(P0.05)。结论单次2 g·kg~(-1)丙种球蛋白联合阿司匹林肠溶片方案治疗川崎病的临床疗效明显优于1 g·kg~(-1)丙种球蛋白2 d联合阿司匹林肠溶片方案,前者可更快地缓解患儿的临床病症情况,降低血清炎症因子的水平,且不增加药物不良反应的发生率。
[Abstract]:Objective to compare the clinical efficacy and safety of gamma globulin combined with aspirin enteric-coated tablets in the treatment of Kawasaki disease. Methods 90 children with Kawasaki disease were randomly divided into control group (n = 45) and experimental group (n = 45). The control group was given 1 g KGG) immunoglobulin intravenously for 2 days and 40 mg KG-1) aspirin enteric-coated tablets for 1 month, while the experimental group was given 2 g kg-1) Gammaglobulin and 40 mg KG-1) Aspirin enteric coated tablets QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD, QD and QD, respectively. It lasts for one month. The clinical efficacy, IL-8, hs-CRP, TNF- 伪, and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 95.5656 / 45 and 84.4443 / 45, respectively. The difference was statistically significant (P 0.05). One month after treatment, the IL-6 of the experimental group and the control group were 6.18 卤2.10) and 9.10 卤3.19)pg / L ~ (-1), respectively (5.17 卤1.01) and 10.27 卤2.15)pg / L ~ (-1) ~ (-1) hs-CRP respectively (2.61 卤1.04) and 5.27 卤0.97)mg ~ (-1) ~ (-1), respectively (P = 13.77 卤0.86) and 16.52 卤1.13)ng ~ (-1), respectively (P 0.05). Adverse drug reactions were nausea and headache in the trial group and nausea, headache and shivering in the control group. The incidence of total adverse drug reactions in the test group and the control group were 17.78% and 13.33%, respectively, with no significant difference (P 0.05). Conclusion the clinical efficacy of a single dose of 2 g kg 路kg ~ (-1) gamma globulin combined with aspirin enteric-coated tablet regimen in the treatment of Kawasaki disease is significantly better than that of 1 g / kg ~ (-1) gamma globulin combined with aspirin enteric-coated tablet regimen for 2 days. The former can relieve the clinical symptoms more quickly in children with Kawasaki disease. Reduce the level of serum inflammatory factors and do not increase the incidence of adverse drug reactions.
【作者单位】：安徽医科大学第一附属医院儿科;安徽省儿童医院急救中心;
【基金】：安徽省卫生厅科研计划基金资助项目(13FR021)
【分类号】：R725.4

【相似文献】