血清多巴胺水平与儿童多动症发生发展的关系及多巴胺受体激动剂的疗效

发布时间：2018-05-16 02:13

本文选题：多巴胺 + 儿童　；参考：《广东医学》2017年20期

【摘要】：目的探讨血清多巴胺水平与儿童多动症发生发展的关系及多巴胺受体激动剂的治疗效果。方法选取多动症儿童46例为观察组,并以同期30例健康查体儿童为对照组。检测比较两组血清多巴胺水平、多动指数等。观察组采用多巴胺受体激动剂治疗,连续治疗半年后评价其疗效。比较治疗有效患者和治疗无效患者的血清多巴胺水平、多动指数,并分析儿童多动症血清多巴胺水平与其多动指数和疗效的关系。结果与对照组比较,观察组血清多巴胺水平降低而多动指数升高(P0.05)。与治疗前比较,观察组治疗后血清多巴胺水平升高而多动指数降低(P0.05)。观察组治疗有效率为86.96%(40/46)。与治疗有效患者比较,其治疗无效患者治疗前后的血清多巴胺水平降低而多动指数升高(P0.05)。Pearson线性相关分析结果显示,多动症儿童血清多巴胺水平与其多动指数呈负相关(r=-0.826,P0.05)。Spearman无条件相关分析结果显示,多动症儿童血清多巴胺水平与其治疗有效率呈正相关(r=0.865,P0.05)。结论血清多巴胺水平与儿童多动症发生发展及疗效相关,且其多巴胺受体激动剂疗效较好。
[Abstract]:Objective to investigate the relationship between serum dopamine level and the development of ADHD and the therapeutic effect of dopamine receptor agonist. Methods 46 children with ADHD were selected as observation group and 30 healthy children as control group. The serum dopamine level and hyperactivity index were measured and compared between the two groups. The treatment group was treated with dopamine receptor agonist. The serum dopamine levels and hyperactivity index were compared between effective and ineffective patients. The relationship between serum dopamine level and hyperactivity index and curative effect in children with ADHD was analyzed. Results compared with the control group, the serum dopamine level decreased and the hyperactivity index increased in the observation group (P 0.05). Compared with before treatment, the serum dopamine level increased and the hyperactivity index decreased in the observation group after treatment (P 0.05). The effective rate of treatment in the observation group was 86.96 / 46. Compared with the effective patients, the serum dopamine level decreased and the hyperactivity index increased before and after the treatment. Pearson linear correlation analysis showed that, There was a negative correlation between serum dopamine level and hyperactivity index in children with ADHD. The results of unconditional correlation analysis showed that the serum dopamine level in ADHD children was positively correlated with the effective rate of hyperactivity disorder (ADHD). Conclusion Serum dopamine level is related to the occurrence, development and curative effect of ADHD, and the effect of dopamine receptor agonist is better.
【作者单位】：华中科技大学同济医学院附属武汉儿童医院康复医学科;
【分类号】：R749.94

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