左乙拉西坦片治疗儿童难治性癫痫的临床研究

发布时间：2018-05-17 12:36

本文选题：左乙拉西坦片 + 卡马西平片　；参考：《中国临床药理学杂志》2017年22期

【摘要】：目的比较左乙拉西坦片与卡马西平片治疗儿童难治性癫痫的临床疗效及安全性。方法将96例难治性癫痫患儿随机分为对照组48例和试验组48例。对照组予以卡马西平4~8 mg·kg~(-1)·d~(-1),分3次口服;试验组予以左乙拉西坦4 mg·kg~(-1),bid,口服,每隔2周增加4 mg·kg~(-1),最高剂量16 mg·kg~(-1)。2组患儿均治疗8个月。比较2组患儿的临床疗效、神经认知功能测评[语言智商(VIQ)、操作智商(PIQ)、总智商(TIQ)及短时视觉记忆(STVM),以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为87.50%(42例/48例)和68.75%(33例/48例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的VIQ评分分别为(106.97±5.65)和(95.25±3.28)分,PIQ分别为(116.45±5.16)和(103.61±2.74)分,TIQ分别为(119.92±4.69)和(95.20±3.24)分,STVM分别为(18.45±2.17)和(13.84±1.81)s,差异均有统计学意义(均P0.05)。2组患者的药物不良反应以情绪激动、嗜睡、心悸、头晕为主,试验组和对照组的药物不良反应发生率分别为12.50%和16.67%,差异无统计学意义(P0.05)。结论左乙拉西坦片治疗难治性癫痫患儿的临床疗效显著优于卡马西平片,前者可显著提高患儿的认知能力,且不增加药物不良反应的发生率。
[Abstract]:Objective to compare the clinical efficacy and safety of levoethoxetam and carbamazepine in the treatment of refractory epilepsy in children. Methods 96 children with refractory epilepsy were randomly divided into control group (n = 48) and experimental group (n = 48). The control group was treated with carbamazepine (4mg / kg), and the control group was given 4 mg / kg / kg ~ (-1) carmazepine, and the control group was treated with levoethoxetam 4 mg / kg / kg ~ (-1) / d ~ (-1) / d ~ (-1) respectively, while the control group was treated with levoethoxetam 4 mg / kg / kg ~ (-1) / L ~ (-1), and the control group was treated with 4 mg / kg ~ (-1) kg~(-1).2 every 2 weeks. To compare the clinical efficacy, neurocognitive function test (VIQT, PIQT, TIQs), STVMN and adverse drug reactions in the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 87.50% / 48 cases and 68.75% / 48 cases, respectively. The difference was statistically significant (P 0.05). After treatment, the VIQ scores of the test group and the control group were 106.97 卤5.65) and 95.25 卤3.28) respectively. The scores of VIQ were 116.45 卤5.16 and 103.61 卤2.74, respectively. The scores of VIQ were 119.92 卤4.69 and 95.20 卤3.24, respectively, which were 18.45 卤2.17 and 13.84 卤1.81s, respectively. The incidence of adverse drug reactions in the experimental group and the control group was 12.50% and 16.67% respectively. There was no significant difference between the two groups (P 0.05). Conclusion the clinical efficacy of levoethylacetam tablets in the treatment of refractory epilepsy children is significantly better than that of carbamazepine tablets, the former can significantly improve the cognitive ability of children, and does not increase the incidence of adverse drug reactions.
【作者单位】：常德市第一人民医院小儿内科;首都医科大学附属北京儿童医院功能神经外科;
【分类号】：R742.1

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