匹多莫德和脾氨肽对呼吸道反复感染儿童外周血T细胞亚群及其细胞因子的影响

发布时间：2018-05-29 00:43

本文选题：反复呼吸道感染 + 免疫力　；参考：《中华医院感染学杂志》2017年01期

【摘要】：目的比较匹多莫德和脾氨肽对呼吸道感染儿童外周血T细胞亚群及其细胞因子的影响,并分析临床疗效。方法选取2014年1月-2015年1月呼吸道反复感染患儿100例,将患儿随机分为研究组和对照组,每组50例;两组均给予抗感染、化痰液、降温等对症支持治疗,研究组在此基础上给予匹多莫德治疗,对照组给予脾氨肽治疗;比较两组患者的临床疗效、外周血T细胞亚群(CD4+和CD8+T细胞)和外周血细胞因子。结果研究组痊愈率、显效率、有效率和无效率分别为34.0%、36.00%、20.00%和10.00%,对照组分别为16.00%、36.00%、28.00%和20.00%,差异有统计学意义(P=0.026);研究组痊愈率显著高于对照组(P=0.038);两组患儿治疗后CD4+T细胞水平均明显升高(P0.05);与对照组比较,治疗后3月研究组CD4+T细胞显著升高[(36.38±4.88)%vs(32.29±4.21)%,P=0.002)];两组患儿治疗后IL-4水平均显著降低,IFN-γ水平均显著升高(P0.05);与对照组比较,治疗后3月研究组IL-4水平显著降低[(26.39±8.38)pg/ml vs(45.39±9.49)pg/ml,P=0.000];IFN-γ水平显著升高[(35.93±12.49)ng/ml vs(25.39±8.86)ng/ml,P=0.000]。结论匹多莫德有助于提高反复呼吸道感染儿童免疫力,降低复发率。
[Abstract]:Objective to compare the effects of Pi do Maude and spleen Aminopeptide on the peripheral blood T cell subsets and its cytokines in children with respiratory infection, and to analyze the clinical effect. Methods 100 children with recurrent respiratory tract infection in January January 2014 were selected and divided into the study group and the control group, 50 cases in each group, and the two groups were all given anti infection, phlegm solution, and cooling. On the basis of the symptomatic support treatment, the study group was given Pi do Maude therapy on this basis, and the control group was treated with spleen Aminopeptide; the clinical efficacy of the two groups, the peripheral blood T cell subgroup (CD4+ and CD8+T cells) and peripheral blood cytokines were compared. The recovery rate, efficiency, efficiency and inefficiency of the study group were 34%, 36%, 20% and 10%, respectively, respectively. The control group was 16%, 36%, 28% and 20% respectively (P=0.026), and the recovery rate of the study group was significantly higher than that of the control group (P=0.038); the level of CD4+T cells in the two groups increased significantly (P0.05) after treatment. Compared with the control group, the CD4+T cells in the study group increased significantly [(36.38 + 4.88)%vs (32.29 + 4.21)%, P=0.002) in the March group. The level of IL-4 in the two groups was significantly reduced and IFN- gamma water increased significantly (P0.05). Compared with the control group, the level of IL-4 in the study group was significantly lower [(26.39 + 8.38) pg/ml vs (45.39 + 9.49) pg/ml, P=0.000], and IFN- gamma (35.93 + 12.49) ng/ml vs (25.39 + 8.86) ng/ml. Improve the immunity of children with recurrent respiratory tract infection and reduce the recurrence rate.
【作者单位】：浙江省浦江县人民医院儿科;
【基金】：浙江省医药卫生一般研究计划项目(2014KYA186)
【分类号】：R725.6

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