不同过敏家族史婴幼儿发生食物过敏的围生期环境影响因素分析

发布时间：2018-05-29 08:18

本文选题：食物致敏 + 食物过敏　；参考：《重庆医科大学学报》2017年08期

【摘要】：目的:探讨围生期环境因素对不同过敏家族史婴幼儿发生食物致敏及过敏的影响。方法:回顾性分析进行食物过敏流行病学调查的婴幼儿问卷资料2 030份。对不同过敏家族史婴幼儿发生食物致敏及过敏的围生期环境因素进行logistic回归分析。结果:家族史阳性儿童食物致敏及过敏的检出率明显高于家族史阴性儿童(致敏:27.1%vs.15.3%,χ2=35.752,P=0.000;过敏:19.5%vs.9.7%,χ2=34.472,P=0.000);62.5%食物致敏、59.5%食物过敏婴幼儿来自过敏疾病家族史阴性的儿童。对于过敏疾病家族史阳性儿童,孕期高蛋白摄入可导致食物致敏(OR=1.618,95%CI=1.085~2.414,P=0.018)。对于家族史阴性的儿童,高出生体质量、生后头3 d最早摄入非母乳食物、孕期高蛋白摄入可增加其发生食物致敏的风险(OR=1.674,95%CI=1.115~2.515,P=0.013;OR=1.396,95%CI=1.040~1.875,P=0.026;OR=1.996,95%CI=1.495~2.664,P=0.000);高出生体质量、孕期高蛋白摄入亦是此类婴幼儿发生食物过敏的危险因素(OR=1.794,95%CI=1.104~2.916,P=0.018;OR=1.797,95%CI=1.269~2.546,P=0.001)。结论:虽然过敏性家族史阳性者更易发生食物致敏及过敏;然而,家族史阴性者更易受围生期环境因素影响。
[Abstract]:Objective: to investigate the effect of perinatal environmental factors on food sensitization and allergy in infants with different family history of allergy. Methods: the data of 20 30 infant and young children questionnaire were retrospectively analyzed. The perinatal environmental factors of food sensitization and allergy in infants with different family history of allergy were analyzed by logistic regression analysis. Results: the detection rates of food sensitization and allergies in children with positive family history were significantly higher than those in children with negative family history (sensitizing 27.1vs.15.3, 蠂 ~ 2 + 35.752) 0.000; allergies: 19.5vs.9.7; 62.5% of children with food allergies came from family history of allergic diseases (59.5%). For children with positive family history of allergic diseases, high protein intake during pregnancy may lead to food sensitization. For children with negative family history, high birth weight, the earliest intake of non-breast milk food in the first three days after birth, high protein intake during pregnancy increased the risk of food sensitization. High protein intake during pregnancy is also a risk factor for food allergies in these infants and children. Conclusion: although allergic family history positive people are more likely to develop food sensitization and allergies, however, negative family history is more susceptible to perinatal environmental factors.
【作者单位】：重庆医科大学附属儿童医院儿童保健科儿童发育疾病研究教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室;
【分类号】：R725.9

【相似文献】