SHR、WKY大鼠与SD大鼠注意缺陷多动障碍模型行为学特征的比较

发布时间：2018-05-30 22:46

本文选题：注意缺陷多动障碍 + 动物模型　；参考：《中国实验动物学报》2017年04期

【摘要】：目的比较SHR、WKY、SD大鼠行为学特征,探寻研究SHR大鼠注意缺陷多动障碍(ADHD)理想的对照模型。方法运用旷场实验统计大鼠运动距离、运动速度、穿格数及理毛次数来评价SHR、WKY、SD大鼠自主运动情况;运用水迷宫实验检测三组大鼠的学习记忆能力。结果旷场实验结果显示,SHR大鼠在总运动量、平均运动速度及穿格次数上较WKY及SD大鼠均显著增加(P0.01);与WKY大鼠相比,SD大鼠运动距离显著高于WKY组(P0.01),其运动速度及穿格数略高于WKY组(P0.05);水迷宫隐匿站台实验中,与SHR大鼠相比,SD大鼠潜伏期较长(P0.05),在潜伏期运动距离上,SD大鼠在训练第1天、第3天及第4天运动距离较SHR大鼠延长(P0.05或P0.01);比较WKY组,SD大鼠潜伏期及潜伏期运动距离较WKY在各个训练时间均有不同程度的下降(P0.05或P0.01)。在空间探索阶段,SD大鼠穿台次数及目标象限运动时间、距离比率等均较SHR大鼠有所减少(P0.05),而较WKY大鼠则有不同程度的升高(P0.05或P0.01)。结论 WKY大鼠与SHR大鼠行为学差异过大,两者的比较存在一定的不足,增设SD大鼠作为SHR大鼠的对照组能够提升SHR大鼠行为学特征的可比性,更为客观的反映SHR大鼠的行为学特征。
[Abstract]:Objective to compare the behavioral characteristics of SHR-WKYSD rats and to explore an ideal control model for the study of ADHD in SHR rats with attention deficit hyperactivity disorder (ADHD). Methods Open field experiment was used to evaluate the spontaneous movement of SHR-WKYYSD rats, and the learning and memory abilities of the three groups were measured by water maze test. Results the results of open field experiment showed that the total exercise amount of SHR rats was higher than that of SHR rats. Compared with WKY and SD rats, the average exercise speed and the number of piercing were significantly higher in SD rats than those in WKY and SD rats, and the distance between SD rats and WKY rats was significantly higher than that in WKY rats, and the speed and number of traverses were slightly higher than that in WKY group. In the water maze occult platform experiment, the average movement speed and the number of traversals in SD rats were slightly higher than those in WKY group. The incubation period of SD rats was longer than that of SHR rats. On the 3rd and 4th day, the exercise distance was significantly longer than that of SHR rats (P0.05 or P0.01), and the latency and latency of SD rats in WKY group were significantly lower than that of WKY in different training time (P0.05 or P0.01). At the stage of space exploration, the number of platform penetration, the time of target quadrant movement and the distance ratio of Sprague-Dawley rats were decreased compared with those of SHR rats, while those of WKY rats were significantly higher than those of WKY rats (P0.05 or P0.01). Conclusion the behavioral differences between WKY rats and SHR rats are too great, and there are some deficiencies in the comparison between them. The addition of SD rats as the control group of SHR rats can enhance the comparability of the behavioral characteristics of SHR rats. The behavioral characteristics of SHR rats were more objectively reflected.
【作者单位】：南京中医药大学中医儿科研究所;
【基金】：国家自然科学基金面上项目(编号:81273801) 江苏省教育厅研究生创新学习计划项目(KYZZ16_0410)
【分类号】：R-332;R749.94

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