急性腹泻患儿血清25-羟维生素D与炎性细胞因子水平的关系

发布时间：2018-06-03 22:03

本文选题：急性腹泻 + -羟维生素D　；参考：《山东医药》2017年10期

【摘要】：目的探讨急性腹泻患儿血清25-羟维生素D[25(OH)D]与炎性细胞因子水平的关系。方法选取60例急性腹泻患儿(腹泻组)及健康体检正常的60例儿童(对照组),测定血清25(OH)D及炎性细胞因子白细胞介素2(IL-2)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)。结果腹泻组血清25(OH)D水平低于对照组,血清IL-2、IL-6、TNF-α、IFN-γ水平高于对照组(P均0.05);腹泻组病程3 d、腹泻次数10次/d、重度脱水患儿血清25(OH)D水平低于病程≤3 d、腹泻次数≤10次/d、轻中度脱水患儿(P均0.05);腹泻组患儿血清25(OH)D与IL-2、IL-6、TNF-α、IFN-γ水平均呈负相关(r分别为-0.75、-0.56、-0.59、-0.82,P均0.05)。结论急性腹泻患儿存在25(OH)D丢失及炎性细胞因子的升高,两者血清水平呈负相关。
[Abstract]:Objective to investigate the relationship between serum 25- hydroxyvitamin D[25 (OH) D] and inflammatory cytokine levels in children with acute diarrhea. Methods 60 children with acute diarrhea (diarrhea group) and 60 normal healthy children (control group) were selected to determine serum 25 (OH) D and inflammatory cytokines interleukin 2 (IL-2), interleukin 6 (IL-6), and tumor necrosis factor alpha (T). NF- alpha), interferon gamma (IFN- gamma). The serum level of 25 (OH) D in the diarrhea group was lower than that of the control group. The level of serum IL-2, IL-6, TNF- a, IFN- gamma was higher than that of the control group (P 0.05); the course of diarrhea in the diarrhea group was 3 D, the number of diarrhea was 10 times /d, and the level of 25 (OH) in the severe dehydrated children was lower than that of the disease course less than 3, and the number of diarrhoea less than 10 times, and the children with mild and moderate dehydration (0.05); diarrhea group The serum levels of 25 (OH) D were negatively correlated with IL-2, IL-6, TNF- alpha and IFN- gamma (R respectively -0.75, -0.56, -0.59, -0.82, P are 0.05). Conclusions 25 of children with acute diarrhoea were lost and inflammatory cytokines were elevated, and the serum levels were negatively correlated.
【作者单位】：秦皇岛市第一医院;
【基金】：河北省秦皇岛市科学技术研究与发展计划项目(201401A126)
【分类号】：R725.7

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