丙泊酚预防小儿全麻术后苏醒期躁动的剂量探讨

发布时间：2018-06-04 21:19

本文选题：全身麻醉 + 小儿　；参考：《山东医药》2017年33期

【摘要】：目的探究不同剂量的丙泊酚对小儿全麻术后苏醒期躁动的干预效果,确定丙泊酚应用的最佳剂量。方法选择择期行腺样体切除的患儿120例,按照随机数字表法分成A、B、C、D四组各30例。麻醉诱导选用2μg/kg芬太尼、2.0 mg/kg的丙泊酚与0.1 mg/kg的顺式阿曲库铵,维持用3%的七氟烷。手术结束即刻为A组静脉注射0.1 m L/kg生理盐水,B、C、D组分别静脉注射1.0、1.5、2.0 mg/kg的丙泊酚。观察四组术后气管拔管时间、自主呼吸恢复时间、麻醉复苏室(PACU)滞留时间以及苏醒标准评分(Aldrete评分)、躁动评分(PAED评分)、镇静效果评分(Remesay评分)。结果四组气管拔管时间、自主呼吸恢复时间及改良Aldrete评分、Remesay评分比较差异无统计学意义(P均0.05);B组PACU滞留时间与其他三组比较明显缩短,躁动发生率、PAED评分低于其他三组(P均0.05)。结论全麻术后苏醒期静脉注射1.0 mg/kg的丙泊酚可以减少患儿在PACU滞留时间,是预防术后苏醒期躁动的最佳剂量。
[Abstract]:Objective to investigate the effect of propofol on restlessness after general anesthesia in children and determine the best dose of propofol. Methods 120 children with selective adenoidectomy were randomly divided into four groups (30 cases each). 2 渭 g/kg fentanyl 2.0 mg/kg propofol and 0.1 mg/kg cis atracurium were used to induce anesthesia and 3% sevoflurane was maintained. At the end of operation, propofol was injected intravenously into group A (0.1 mL / kg normal saline) and propofol (2.0 mg/kg) respectively. The time of tracheal extubation, the recovery time of spontaneous respiration, the retention time of anaesthesia resuscitation chamber (PACUU), the recovery standard score (Aldrete score), the restlessness score (PAED) and the sedative effect score (Remesay score) were observed in the four groups. Results there was no significant difference in tracheal extubation time, spontaneous respiration recovery time and modified Aldrete score between the four groups (P < 0.05). The retention time of PACU in group B was significantly shorter than that in the other three groups, and the rate of restlessness was lower than that in the other three groups (P < 0.05). Conclusion intravenous injection of propofol 1.0 mg/kg after general anesthesia can reduce the retention time of PACU and is the best dose of propofol to prevent restlessness during postoperative recovery.
【作者单位】：西南医科大学附属中医院;
【分类号】：R726.1

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