儿童支气管哮喘与母孕期及新生儿期相关影响因素分析

发布时间：2018-06-12 00:45

本文选题：支气管哮喘 + 妊娠期　；参考：《中国当代儿科杂志》2017年01期

【摘要】：目的分析儿童支气管哮喘在母孕期及新生儿期的影响因素,为早期防治儿童哮喘提供依据。方法选择306例哮喘患儿(哮喘组)和250例正常儿童(对照组),对所有儿童母孕期和新生儿期的临床资料进行调查。结果单因素分析显示哮喘组与对照组在孕期使用抗生素、新生儿期使用抗生素、新生儿期服用益生菌、早产、剖宫产、低出生体重、母乳喂养方面比较差异有统计学意义(P0.05)。多因素logistic回归分析显示,孕期使用抗生素(OR=3.908,95%CI:1.277~11.962)、新生儿期使用抗生素(OR=24.154,95%CI:7.864~74.183)、早产(OR=8.535,95%CI:2.733~26.652)及剖宫产(OR=4.588,95%CI:2.887~7.291)为儿童哮喘的独立危险因素;而新生儿期服用益生菌(OR=0.014,95%CI:0.004~0.046)及母乳喂养6个月(OR=0.161,95%CI:0.103~0.253)为儿童哮喘的保护因素。结论孕期减少抗生素的使用、减少剖宫产、新生儿期避免滥用抗生素、尽量母乳喂养、尽早添加益生菌可对儿童哮喘起到一定的早期预防作用。
[Abstract]:Objective to analyze the influencing factors of childhood bronchial asthma during pregnancy and neonatal period, and to provide evidence for early prevention and treatment of childhood asthma. Methods 306 asthmatic children (asthma group) and 250 normal children (control group) were investigated. Results univariate analysis showed that there were significant differences between asthma group and control group in using antibiotics during pregnancy, preterm delivery, cesarean section, low birth weight and breast feeding. Multivariate logistic regression analysis showed that the use of antibiotics OR3.908 / 95CI: 1.277 / 11.962 during pregnancy, 24.1544 / 95CI: 7.864 / 74.183 in neonatal period, 8.53595 / 95CI2.7335CI2.7336.652in preterm delivery) and 4.58895CIW 2.8887 / 7.291in cesarean section were independent risk factors for children's asthma. The protective factors of asthma in children were the probiotics in newborn stage: 0.014 ~ 95% CI: 0.004 ~ 0.046) and breast-feeding for 6 months (Ori 0.161 ~ 95 CI: 0.103 ~ 0.253). Conclusion reducing the use of antibiotics during pregnancy, reducing cesarean section, avoiding the abuse of antibiotics in neonatal period, breast-feeding as far as possible and adding probiotics as early as possible can play an early role in preventing asthma in children.
【作者单位】：第四军医大学西京医院儿科;

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