妇女围孕期特殊危险因素暴露对新生儿出生缺陷的影响

发布时间：2018-06-12 01:52

本文选题：出生缺陷 + 特殊危险因素暴露　；参考：《西安交通大学学报(医学版)》2017年03期

【摘要】：目的探讨妇女围孕期特殊危险因素暴露对于新生儿出生缺陷的影响。方法于2013年7-12月采用分层多阶段随机抽样方法,以陕西省抽取2010-2013年期间曾经妊娠的15~49岁育龄妇女及其子女为调查对象,调查围孕期特殊危险因素暴露情况,采用Logistic回归模型分析这些危险因素与新生儿出生缺陷的关系。结果本研究共纳入调查育龄妇女30 010名,新生儿29 550例,出生缺陷发生率为193.57/万。对妇女围孕期特殊危险因素分析发现,校正社会人口学等因素后,围孕期饮酒[OR=2.29,95%CI(1.22,4.29)]和被动吸烟[OR=1.25,95%CI(1.02,1.53)]是出生缺陷发生的危险因素,而在孕前3个月和孕后3个月服用药物[OR=1.64,95%CI(1.04,2.61)],接触农药[OR=2.41,95%CI(1.09,5.35)]、生物危险因素[OR=1.64,95%CI(1.05,2.56)]、物理危险因素[OR=1.15,95%CI(1.13,2.34)]和化学危险因素[OR=2.36,95%CI(1.36,4.11)]显著增加新生儿出生缺陷的风险。进一步就不同类型药物对出生缺陷的影响分析发现,校正社会人口学因素及生活行为因素后,水杨酸类药物和镇咳药是新生儿出生缺陷的危险因素(P0.05)。结论妇女围孕期有被动吸烟和饮酒、孕前3个月至孕3个月暴露药物、生物和理化危险因素可增加其分娩新生儿出生缺陷的发生风险。
[Abstract]:Objective to investigate the effect of exposure to special risk factors during pregnancy on neonatal birth defects. Methods from July to December 2013, a stratified multi-stage random sampling method was used to investigate the exposure to special risk factors of 1549 years old women and their children who had been pregnant from 2010 to 2013 in Shaanxi Province. Logistic regression model was used to analyze the relationship between these risk factors and neonatal birth defects. Results A total of 30 010 women of childbearing age and 29 550 newborns were investigated in this study. The incidence of birth defects was 193.57 / 10 000. According to the analysis of the special risk factors of women during pregnancy, after adjusting for social demographics and other factors, drinking during pregnancy [OR 2.2995 CI1.224.29] and passive smoking [OR1.25 ~ 95CI1.02C 1.53] were risk factors of birth defects. However, three months before pregnancy and three months after pregnancy, exposure to pesticides (OR2.4195 CIQ 1.095.35), biological risk factors [OR1.16495CII 1.0552.56], physical risk factors [OR1.1595CII 1.132.34] and chemical risk factors [OR2.3695CII 1.364.11] significantly increased the risk of neonatal birth defects. Further analysis on the effects of different drugs on birth defects showed that salicylic acid and antitussive drugs were the risk factors of birth defects in newborns after adjusting for social demographic factors and life behavior factors. Conclusion Women have passive smoking and drinking during pregnancy and exposure to drugs from 3 months before pregnancy to 3 months of pregnancy. Biological and physical and chemical risk factors can increase the risk of birth defects in their newborn babies.
【作者单位】：西安交通大学公共卫生学院流行病与卫生统计学系;
【基金】：国家自然科学基金资助(No.81230016) 陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013)~~
【分类号】：R722.1

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