肥胖对不同年龄段哮喘患儿肺功能的影响

发布时间：2018-06-12 16:16

本文选题：哮喘 + 体重指数　；参考：《中国当代儿科杂志》2017年05期

【摘要】：目的研究肥胖对不同年龄段初诊哮喘患儿肺功能的影响。方法 294名初诊哮喘患儿按年龄分为学龄前期组(6岁)及学龄期组(6~12.5岁),并根据不同体重指数(BMI)分为体重正常哮喘组、超重哮喘组及肥胖哮喘组,检测患儿肺功能,包括大气道通气功能指标[用力肺活量(FVC)、第1秒用力呼气量(FEV1)]和小气道通气功能指标[用力呼气25%、50%及75%流量的实测值占预计值的百分比,即MEF25%、MEF50%、MEF75%]。结果在校正了性别及BMI分组因素后,学龄期组FEV1%、MEF25%、MEF50%低于学龄前期组(P0.05)。两年龄组正常体重患儿间比较,学龄期组基础肺功能FEV1%、MEF25%、MEF50%低于学龄前期组(P0.05);两年龄组超重患儿间比较,学龄期组FVC%及MEF50%低于学龄前期组;两年龄组肥胖患儿间比较,肺功能各指标差异均无统计学意义。学龄前期肥胖组FVC%、FEV1%及MEF75%均低于体重正常组,而学龄期肥胖组仅FVC%和FEV1%与体重正常组间差异有统计学意义(P0.05)。结论肥胖对哮喘患儿基础肺功能的影响存在年龄差异,于学龄前期更明显。
[Abstract]:Objective to study the effect of obesity on lung function in children with primary asthma at different age groups. Methods 294 children with primary asthma were divided into pre school age group (6 years old) and school age group (6~12.5 years), and they were divided into normal weight asthma group, overweight asthma group and obese asthma group according to different body mass index (BMI), and the lung function, including large airway, was detected. Ventilatory function index [forced vital capacity (FVC), 1 second forced expiratory volume (FEV1)] and small airway ventilation function index [percentage of measured values of 25%, 50%, and 75% flow of forced expiratory flow, that is, MEF25%, MEF50%, MEF75%]. results, after the correction of gender and BMI grouping factors, the school age group FEV1%, MEF25%, MEF50% lower than the pre school age group (P0.05). In the two age group, the basic lung function FEV1%, MEF25% and MEF50% in the school age group were lower than the pre school age group (P0.05), the two age group was compared with the overweight children, the school age group FVC% and the MEF50% were lower than the pre school age group; the two age group was compared with the obese children, and there was no statistical difference between the indexes of the lung function. The pre school obesity group FV was not statistically significant. C%, FEV1% and MEF75% were lower than the normal weight group, but there was a significant difference between the obese group and the normal body weight group (P0.05) in the school age obese group (P0.05). Conclusion the effect of obesity on the basic lung function of children with asthma was different in age, and was more obvious in the early stage of school age.
【作者单位】：重庆医科大学附属儿童医院呼吸中心/儿童发育疾病研究教育部重点实验室/儿科学重庆市重点实验室/儿童发育重大疾病国家国际科技合作基地;
【基金】：重庆市卫生局医学科研项目资助(2012-2-96)
【分类号】：R725.6

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