双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎的临床观察

发布时间：2018-06-12 17:11

本文选题：双环醇 + 更昔洛韦　；参考：《中国药房》2017年23期

【摘要】：目的:探究双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎的临床疗效及安全性。方法:选取2012年5月-2015年8月我院儿科收治的巨细胞病毒性肝炎患儿120例,按随机数字表法分为观察组和对照组,各60例。两组患儿均给予常规治疗,包括保肝、补充维生素C和维生素K等,并给予复方甘草酸苷注射液20 m L,ivgtt,qd。对照组患儿在上述治疗的基础上给予更昔洛韦葡萄糖注射液(诱导期5 mg/kg,q12 h,每次滴注时间1 h,持续7 d;维持期5 mg/kg,q24 h,持续7 d);观察组患儿在对照组的基础上口服双环醇片0.5 mg/kg,bid。观察两组患儿临床疗效及治疗前后肝酶、黄疸水平,并比较CMV转阴率及不良反应发生情况。结果:观察组患儿临床总有效率为93.3%,显著高于对照组的80.0%,差异有统计学意义(P0.05)。治疗前,两组患儿肝酶和黄疸水平比较,差异均无统计学意义(P0.05);治疗后,两组患儿肝酶和黄疸水平均显著降低,且观察组水平显著低于对照组,差异均有统计学意义(P0.05)。观察组患儿CMV总转阴率为85.0%,显著高于对照组的73.3%,差异有统计学意义(P0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P0.05)。结论:双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎疗效显著,能有效降低患儿血清肝酶水平、消除黄疸、保护肝功能、促进病毒转阴,且安全性较高。
[Abstract]:Objective: to investigate the efficacy and safety of bicyclol combined with ganciclovir in the treatment of infantile cytomegalovirus hepatitis. Methods: 120 children with cytomegalovirus hepatitis from May 2012 to August 2015 were randomly divided into observation group (n = 60) and control group (n = 60). Both groups were given routine treatment, including liver protection, supplementation of vitamin C and vitamin K, and 20 mL of compound glycyrrhizin injection iv GTT QD. The control group was given ganciclovir glucose injection (5 mg 路kg ~ (-1) 路kg ~ (-1) for 12 h, each time for 7 days, while the maintenance period was 5 mg / kg ~ (-1) Q for 24 h for 7 days, and the observation group was given dicyclol tablet 0.5 mg 路kg ~ (-1) bid on the basis of the control group, and the control group was treated with ganciclovir glucose injection (5 mg 路kg ~ (-1) 路kg ~ (-1) for 12 h. The clinical curative effect, liver enzyme and jaundice were observed before and after treatment, and the negative rate of CMV and the incidence of adverse reactions were compared between the two groups. Results: the total clinical effective rate of the observation group was 93.3, which was significantly higher than that of the control group (80.05%), and the difference was statistically significant (P 0.05). Before treatment, the levels of liver enzyme and jaundice were not significantly different between the two groups, but the levels of liver enzyme and jaundice in the two groups were significantly lower than those in the control group (P 0.05). The total negative rate of CMV in the observation group was 85.0, which was significantly higher than that in the control group (73.3%), and the difference was statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: bicyclol combined with ganciclovir is effective in the treatment of infantile cytomegalovirus hepatitis. It can effectively reduce serum hepatic enzyme level, eliminate jaundice, protect liver function and promote virus negative conversion.
【作者单位】：南阳医学高等专科学校第一附属医院儿科;南阳医学高等专科学校第二附属医院内科;
【分类号】：R725.1

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