轻度胃肠炎伴婴幼儿良性惊厥临床特点及随访

发布时间：2018-06-28 12:56

本文选题：轻度胃肠炎 + 良性惊厥　；参考：《苏州大学》2013年硕士论文

【摘要】：目的：探讨轻度胃肠炎伴婴幼儿良性惊厥(Benign Infantile Convulsions with Mild Gastroenteritis, BICE)的临床特点及预后。方法：对2008年2月至2013年2月常州市第一人民医院儿科住院治疗的63例BICE患儿和69例急性胃肠炎不伴有惊厥患儿进行临床分析,病愈后予2个月～74个月的随访,回顾分析BICE临床、实验室检查结果及预后。49/63例BICE患儿行粪便人轮状病毒(human rotavirus, HRV)抗原检测,比较分析12例粪便HRV抗原阳性BICE患儿与37例阴性BICE患儿临床及实验室检查之间的异同。另比较分析63例BICE患儿和69例急性胃肠炎不伴惊厥患儿实验室检查的差异。结果：63例BICE患儿,年龄6个月～35个月；男27例,女36例；冬季发病22例,秋季发病37例。首次惊厥于腹泻第1天15例,第2天23例,第3天21例,第4天4例。发作形式58/63例为全身性强直阵挛发作；5/63例为部分性发作,惊厥停止后未予抗癫痫治疗。发作间期脑电图4例轻度异常,1例示不正常脑电图。血、尿、粪、肝功能、血生化、脑脊液、头颅CT等检查正常。神经系统查体阴性。粪便HRV阳性患儿血钠、钙含量低于HRV阴性者(131.31±1.94vs133.49±2.92,2.24±0.23vs2.43±0.15,P均0.05)。63例BICE患儿的血钠较69例急性胃肠炎不伴惊厥患儿血钠低(133.03±3.08vs135.37±4.50,P0.05)。随访4例复发,其中1例发生热性惊厥1次,随访期内无转化为癫痫病例。结论：1.根据BICE临床特点,结合相关检查,提示本病可能主要与轮状病毒等感染有关。2.经治疗及随访,发现本病预后良好。
[Abstract]:Objective: to investigate the clinical features and prognosis of mild gastroenteritis with benign convulsions with Mild Gastroenteritis (Bice). Methods: from February 2008 to February 2013, 63 cases of Bice and 69 cases of children with acute gastroenteritis without convulsion in pediatrics of the first people's Hospital of Changzhou were analyzed. The patients were followed up for 2 months to 74 months after recovery. The clinical, laboratory results and prognosis of stool rotavirus (human rotavirus,) antigens in 49 / 63 cases were analyzed retrospectively. The differences and similarities between the clinical and laboratory tests of 12 cases of stool (human rotavirus, antigen positive children and 37 cases of negative Bice children were compared and analyzed. The difference of laboratory examination between 63 cases of nice and 69 cases of acute gastroenteritis without convulsion was analyzed. Results Sixty-three cases of Bee were aged from 6 months to 35 months, including 27 males and 36 females, 22 in winter and 37 in autumn. The first convulsion occurred on the first day (15 cases), the second day (23 cases), the third day (21 cases) and the fourth day (4 cases). There were 58 / 63 cases with generalized tonic-clonic seizure and 5 / 63 cases with partial seizure. No antiepileptic treatment was given after the convulsion stopped. Interictal electroencephalogram (EEG) showed slight abnormality in 4 cases and abnormal EEG in 1 case. Blood, urine, feces, liver function, blood biochemistry, cerebrospinal fluid, cranial CT and other normal examination. Nervous system test negative. The serum sodium and calcium content in stool HRV-positive children were lower than those in HRV-negative patients (131.31 卤1.94vs133.49 卤2.92 卤2.24 卤0.15) .63 cases of nice were lower than 69 cases of acute gastroenteritis without convulsion (133.03 卤3.08vs135.37 卤4.50 P 0.05). 4 cases were followed up, one of them developed febrile convulsion once, and there was no change to epilepsy during the follow-up period. Conclusion 1. According to the clinical characteristics of spice and related examination, it is suggested that the disease may be mainly related to rotavirus infection. After treatment and follow-up, it was found that the prognosis of the disease is good.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R725.7

【参考文献】