儿童重症肺炎支原体肺炎红细胞分布宽度与心肌损害的相关性分析

发布时间：2018-07-09 09:48

  本文选题：肺炎 + 支原体　； 参考：《中国全科医学》2017年S1期

【摘要】：目的探讨儿童重症肺炎支原体肺炎(SMPP)红细胞分布宽度(RDW)与心肌损害的相关性分析。方法选取瑞安市人民医院2013—2017年收治的142例SMPP患儿为研究对象,按照住院期间是否发生心肌损害分为心肌损害组(n=40)和非心肌损害组(n=102),收集两组一般临床资料及实验室检查指标,利用Logistic回归方程分析RDW与SMPP患儿发生心肌损害的关系。结果心肌损害组发热持续时间≥7 d、应用大环内酯类药物时间≥7 d、糖皮质激素应用起始时间≥7 d、肺炎支原体(MP)抗体滴度≥1∶80、血清肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、N-末端脑钠肽前体(NT-pro BNP)、C反应蛋白(CRP)水平高于与非心肌损害组,差异有统计学意义(P0.05);心肌损害组RDW[(15.91±1.14)%]水平高于非心肌损害组[(14.75±1.17)%](t=5.352,P0.05);RDW增高患者中CK-MB、cTnI、NT-pro BNP、CRP水平高于RDW正常患者,差异有统计学意义(P0.05);RDW增高患者中心肌损害发生率(42.3%)高于RDW正常患者(20.0%),差异有统计学意义(χ~2=5.145,P0.05);Pearson相关分析显示,RDW水平与CK-MB、cTnI、NT-pro BNP、CRP水平呈正相关(P0.05);多因素Logistic回归分析显示:RDW是SMPP患儿发生心肌损害的独立危险因素[OR=1.243,95%CI(1.136,1.551),P0.05]。结论机体高水平RDW可能是SMPP患儿发生心肌损害的独立预测因素,临床检测RDW水平对评估此类患儿病情及预后具有一定的临床意义。
[Abstract]:Objective to investigate the correlation between erythrocyte distribution width (RDW) and myocardial damage in children with severe mycoplasma pneumoniae pneumonia (SMPP). Methods 142 children with SMPP admitted in Ruian people's Hospital from 2013 to 2017 were selected as subjects. Myocardial damage was divided into two groups according to whether myocardial damage occurred during hospitalization. The general clinical data and laboratory parameters were collected, and the relationship between RDW and SMPP was analyzed by Logistic regression equation. Results in the myocardial injury group, the duration of fever was more than 7 days, the administration time of macrolides 鈮，

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