红霉素序贯疗法对支原体肺炎患儿免疫球蛋白、细胞因子水平的影响研究

发布时间：2018-07-22 21:03

【摘要】：目的探讨红霉素序贯疗法对支原体肺炎患儿免疫球蛋白、细胞因子变化以及对患儿预后的影响。方法选择2014年2—9月就诊于本院儿科的支原体肺炎患儿118例,采用随机数字表法将患儿分为观察组与对照组各59例。观察组采用红霉素序贯疗法,对照组采用常规红霉素单纯静脉滴注疗法,比较两组患儿的免疫球蛋白、细胞因子水平及患儿预后(有效率及不良反应发生率)。结果治疗前,两组IgA、IgM、IgG水平比较,差异无统计学意义(P0.05);治疗后,观察组的IgA、IgM、IgG水平均较对照组升高,差异有统计学意义(P0.05)。治疗前,两组IL-6、IL-8比较,差异均无统计学意义(P0.05);治疗后,观察组的IL-6、IL-8水平低于对照组,差异有统计学意义(P0.05)。观察组患儿的有效率高于对照组,差异有统计学意义(P0.05)。观察组仅1例发生皮疹,对照组发生胃肠道反应2例、皮疹3例、药物热2例,观察组不良反应发生率低于对照组,差异有统计学意义(P0.05)。结论采用红霉素序贯疗法有助于提高支原体肺炎患儿的免疫球蛋白水平、改善细胞因子水平,在提高患儿治疗有效率的同时,不良反应发生率低,安全性高,值得临床推广。
[Abstract]:Objective to investigate the effect of erythromycin sequential therapy on immunoglobulin, cytokines and prognosis in children with mycoplasma pneumonia. Methods 118 children with mycoplasma pneumonia from February to September 2014 were randomly divided into two groups: observation group (n = 59) and control group (n = 59). The observation group was treated with erythromycin sequential therapy, and the control group was treated with routine erythromycin intravenous drip. The immunoglobulin, cytokine level and prognosis (effective rate and adverse reaction rate) were compared between the two groups. Results before treatment, there was no significant difference between the two groups (P0.05), but after the treatment, the IgG level of the observation group was higher than that of the control group, the difference was statistically significant (P0.05). Before treatment, the two groups of IL-6 IL-8 comparison, there was no statistical significance (P0.05); after treatment, the level of IL-6 IL-8 in the observation group was lower than that in the control group, the difference was statistically significant (P0.05). The effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P0.05). In the observation group, there were only 1 case of rash, 2 cases of gastrointestinal reaction, 3 cases of rash and 2 cases of drug fever in the control group. The incidence of adverse reactions in the observation group was lower than that in the control group (P0.05). Conclusion Erythromycin sequential therapy can improve the level of immunoglobulin and cytokines in children with mycoplasma pneumonia.
【作者单位】：浙江省瑞安市人民医院;
【分类号】：R725.6

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