酚妥拉明联合党参补肺汤治疗婴幼儿喘息性疾病的临床疗效及其对肺功能的影响

发布时间：2018-07-23 11:27

【摘要】：目的探讨酚妥拉明联合党参补肺汤(黄芪、党参、白术等)治疗婴幼儿喘息性疾病的临床疗效及其对肺功能的影响。方法选择2013年8月到2016年4月在我院进行诊治的婴幼儿喘息性疾病94例,随机分为观察组与对照组各47例。对照组给予酚妥拉明治疗,观察组给予酚妥拉明联合党参补肺汤治疗,两组均治疗7 d。结果治疗后观察组与对照组的总有效率分别为97.9%和85.1%,观察组的总有效率明显高于对照组(P0.05)。观察组呼吸困难、咳嗽、发热等症状的消失时间明显快于对照组(P0.05)。观察组面色潮红、烦躁不安、心动过速、恶心呕吐等不良反应总发生率为17.0%,对照组为19.1%,两组对比无明显差异(P0.05)。观察组与对照组治疗后的CD4+值明显低于治疗前(P0.05),而CD8+值明显高于治疗前(P0.05),治疗后观察组的CD4+和CD8+值与对照组对比差异也有统计学意义(P0.05)。观察组与对照组治疗后的FVC值分别为(83.55±15.29)%和(75.20±11.49)%,都明显高于治疗前的(68.24±15.20)%和(69.01±14.03)%(P0.05),观察组治疗后的FVC值也明显高于对照组(P0.05)。结论酚妥拉明联合党参补肺汤治疗婴幼儿喘息性疾病具有良好的安全性,能改善临床症状和免疫功能,从而促进肺功能和治疗效果的改善。
[Abstract]:Objective to investigate the clinical effect of phentoid Lemine combined with Codonopsis decoction (Astragalus, Codonopsis, Atractylodes macrocephala, etc.) in the treatment of infant wheezing diseases and its effect on lung function. Methods from August 2013 to April 2016, 94 infants with wheezing diseases were randomly divided into two groups: the observation group (n = 47) and the control group (n = 47). The control group was treated with Phenotol Lemine, the observation group was treated with phentoid Lemine combined with Codonopsis decoction for 7 days. Results the total effective rates of the observation group and the control group were 97.9% and 85.1%, respectively. The total effective rate of the observation group was significantly higher than that of the control group (P0.05). The time of disappearance of dyspnea, cough and fever in the observation group was significantly faster than that in the control group (P0.05). The total incidence of adverse reactions such as flushing, restlessness, tachycardia, nausea and vomiting was 17.0 in the observation group and 19.1in the control group. There was no significant difference between the two groups (P0.05). The CD4 value of observation group and control group after treatment was significantly lower than that before treatment (P0.05), while CD8 value was significantly higher than that before treatment (P0.05). After treatment, the CD4 and CD8 values of observation group were significantly different from those of control group (P0.05). The FVC values of the observation group and the control group were (83.55 卤15.29)% and (75.20 卤11.49), respectively, which were significantly higher than those before the treatment (68.24 卤15.20)% and (69.01 卤14.03)% (P0.05). The FVC value of the observation group was also significantly higher than that of the control group (P0.05). Conclusion Phenotol Lemine combined with Codonopsis decoction has good safety in the treatment of infant wheezing diseases and can improve clinical symptoms and immune function, thus promoting the improvement of lung function and therapeutic effect.
【作者单位】：河北省中医院儿科;沧州中西医结合医院呼吸科;
【基金】：河北省科技厅项目(15277712D)
【分类号】：R725.6

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