轮状病毒感染患儿的临床特征及相关因素分析

发布时间：2018-07-29 15:08

【摘要】：目的分析轮状病毒感染患儿的临床特征及相关因素,为临床诊疗提供指导依据。方法选取2015年1月-2016年12月来医院就诊的200例腹泻患儿,采用免疫层析胶体金法进行轮状病毒检测,观察轮状病毒的感染情况,流行发病时间、患儿易感年龄、临床特征及血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、干扰素(INF-α)情况;同时搜集患儿的病例资料,单因素统计分析发生轮状病毒感染的相关因素,进一步行多因素回归分析引发感染的高危因素。结果 200例急性腹泻患儿共检出51例轮状病毒,检出率为25.5%;各月龄组患儿的轮状病毒检出率比较,差异有统计学意义(P0.05),其中以6~12月龄患儿的轮状病毒检出率较高;患儿的轮状病毒感染在各季节的检出率比较,差异有统计学意义(P0.05),其中以秋、冬季节检出率较高,分别为39.5%和46.3%;轮状病毒感染患儿在不同性状样便的阳性检出率比较,差异有统计学意义(P0.05),其中在蛋花汤样腹泻患儿的阳性检出率最高,达47.9%;轮状病毒感染患儿的血清IL-2、IL-6、TNF、INF-α表达水平均显著高于非感染组患儿,差异均有统计学意义(P0.05);单因素分析结果显示,母乳喂养、患儿挑食、患儿手卫生、住院时间15d、侵入性检查、抗菌药物连续应用1周及应用肠道微生态制剂与患儿发生轮状病毒感染具有相关性(P0.05);非条件logistic多元素回归分析结果显示,采用母乳喂养、住院时间15d、抗菌药物连续应用1周、应用肠道微生态制剂是轮状病毒感染的独立危险因素。结论轮状病毒在急性腹泻患儿粪便中检出率较高,月龄在6~12个月、秋冬季节、大便性状为蛋花汤样检出率最高;母乳喂养、住院时间15d、抗菌药物连续应用1周及应用肠道微生态制剂与轮状病毒感染密切相关。
[Abstract]:Objective to analyze the clinical characteristics and related factors of rotavirus infection in children and to provide guidance for clinical diagnosis and treatment. Methods 200 children with diarrhea from January 2015 to December 2016 were selected for rotavirus detection by immunochromatographic colloidal gold method. The infection of rotavirus, the time of onset of rotavirus, and the susceptible age of the children were observed. Clinical features and serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor (TNF), interferon (INF- 伪) were collected, and the related factors of rotavirus infection were analyzed by univariate statistical analysis. Further multivariate regression analysis was performed to analyze the risk factors for infection. Results 51 cases of rotavirus were detected in 200 children with acute diarrhea, the detection rate of rotavirus was 25.5%, and the detection rate of rotavirus was significantly higher in children of different months of age (P0.05), and the detection rate of rotavirus was higher in children aged 6 to 12 months. The detection rate of rotavirus infection in different seasons was statistically significant (P0.05). The detection rate of rotavirus infection in autumn and winter was 39.5% and 46.3%, respectively, and the positive rate of rotavirus infection in children with rotavirus infection was higher than that in different traits. The difference was statistically significant (P0.05), in which the positive rate was the highest in children with Egg & vegetable soup like diarrhea (47.9%), and the expression level of IL-2mIL-6 TNFINF- 伪 in serum of children with rotavirus infection was significantly higher than that of non-infected children. All the differences were statistically significant (P0.05). The results of univariate analysis showed that breast feeding, children's picky feeding, hand hygiene, hospital stay for 15 days, invasive examination, Continuous use of antimicrobial agents for 1 week and enteral microecological preparations were associated with rotavirus infection in children (P0.05). The results of multielement regression analysis of non-conditional logistic showed that breast milk was used for 15 days and antibiotics were continuously used for 1 week. The use of intestinal microecological agents is an independent risk factor for rotavirus infection. Conclusion the detection rate of rotavirus in feces of children with acute diarrhea is high. The detection rate of rotavirus is the highest in autumn and winter, the highest in the autumn and winter seasons, and the highest in breast-feeding. Hospital stay for 15 days, continuous use of antibiotics for 1 week and the use of intestinal microecological agents were closely related to rotavirus infection.
【作者单位】：烟台市烟台山医院儿科;烟台市烟台山医院检验科;
【分类号】：R725.1

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