呼出气一氧化氮联合体外过敏原检测对识别反复喘息患儿中哮喘高危患儿的意义

发布时间：2018-08-12 15:48

【摘要】：目的探讨体外过敏原、呼出气一氧化氮(FeNO)联合检测对识别反复喘息患儿中哮喘高危患儿的临床价值。方法选取反复喘息患儿148例(0.5~6岁)为研究对象,80例门诊健康体检儿童为对照组。采用Pharmacia UniCAP免疫检测分析仪测定特异性免疫球蛋白(sIgE),纳库仑一氧化氮分析仪检测FeNO,并评估哮喘预测指数(API)。结果 148例反复喘息患儿中,sIgE阳性102例,阳性率为68.9%,明显高于对照组(11.3%,9/80)(P0.05)。喘息组患儿FeNO检测值及阳性率均明显高于对照组(P0.05)。喘息患儿的API总阳性率为32.4%,而API阳性患儿FeNO检测值为51±6 ppb,明显高于API阴性患儿(13±5 ppb)(P0.05)。sIgE阳性患儿中API阳性检出率为40.2%(41/102),FeNO阳性患儿中API阳性检出率为50.1%(38/73),二者阳性率比较差异无统计学意义。sIgE阳性+FeNO阳性组患儿中API阳性检出率为81.4%,明显高于sIgE、FeNO二者单独阳性组(P0.05)。结论 FeNO、体外过敏原联合检测对反复喘息患儿中哮喘高危患儿的检出率明显优于二者单独检测,二者联合检测为儿童哮喘的早期识别诊断、干预提供了良好的手段。
[Abstract]:Objective to investigate the clinical value of the detection of extracorporeal allergen and exhaled nitric oxide (FeNO) in the identification of asthmatic high risk children with recurrent wheezing. Methods 148 children with recurrent wheezing (0.5 ~ 6 years old) were selected as control group. Pharmacia UniCAP immunoassay was used to detect specific immunoglobulin (sIgE),) and nitric oxide (no) analyzer to detect Feno, and to evaluate the asthma prediction index (API). Results among 148 children with recurrent wheezing, 102 cases were positive for sIgE, the positive rate was 68.9%, which was significantly higher than that in the control group (11.3 / 80) (P0.05). The FeNO detection value and positive rate in asthmatic group were significantly higher than those in control group (P0.05). The total positive rate of API in asthmatic children was 32.4%, while that of API positive children was 51 卤6 ppb, which was significantly higher than that of API negative children (13 卤5 ppb) (P0.05). The positive rate of API was 40.2% (41 / 102). The positive rate of API was 50.1% (38 / 73) in API positive children. The positive rate of API was 81.4 in the FeNO positive group, which was significantly higher than that in the Siga FeNO positive group alone (P0.05). Conclusion the detection rate of Feno and extracorporeal allergen in asthmatic children with high risk of asthma is better than that of both alone. The combined detection of Feno and extracorporeal allergen provides a good method for the early diagnosis and intervention of asthma in children.
【作者单位】：开封市第二人民医院西区分院儿科;
【基金】：开封市科技发展计划项目(1603026)
【分类号】：R725.6

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