流感病毒抗原消失时间探讨
发布时间：2018-08-22 14:47
【摘要】：目的通过免疫荧光抗原检测技术动态监测流感患儿流感病毒抗原,观察患儿抗原转阴时间和临床症状消失时间,以及两者之间的关系。方法对2016年3~4月就诊于湖南省人民医院的1 063例疑似流感患儿运用甲乙型流感病毒抗原检测试剂盒(免疫荧光法)行流感病毒抗原检测,阳性者予以奥司他韦抗病毒治疗;并嘱咐患者起病后5 d内、5~7 d及7 d后3个时间段复查流感病毒抗原。结果 1 063例疑似流感病例中,流感病毒检出560例(52.68%)。对215例流感病毒阳性患儿进行随访,起病5 d内流感病毒抗原转阴率为9.8%(21例),5~7 d内累积转阴率为32.1%(69例),7~10 d累积转阴率为98.1%(211例);起病3 d内临床症状改善率为2.8%(6例),3~5 d临床症状改善累积率为84.7%(182例),5 d后所有患儿临床症状均得到改善。结论流感患儿经治疗临床症状改善时间早于抗原消失时间;起病7~10 d后流感病毒抗原近100%转阴,推测患儿在起病7~10 d、临床症状消失后返校是相对安全的。
[Abstract]:Objective to dynamically monitor influenza virus antigen in children with influenza by immunofluorescence antigen detection technique, and to observe the time of negative change of antigen and the time of disappearance of clinical symptoms, and the relationship between them. Methods from March to April 2016, 1 063 cases of suspected influenza in Hunan Provincial people's Hospital were tested with influenza A and B virus antigen test kit (immunofluorescence method), and those who were positive were treated with oseltamivir antiviral therapy. The patients were ordered to check the influenza virus antigen within 5 days after the onset of the disease and within 5 days and 7 days after the onset of influenza virus antigen. Results among 1 063 suspected influenza cases, 560 cases (52.68%) were detected by influenza virus. 215 cases of influenza virus positive children were followed up. The negative conversion rate of influenza virus antigen within 5 days was 9.8% (21 cases). The cumulative negative conversion rate was 32.1% (69 cases) within 7 days, 98.1% (211 cases) in 10 days, and 2.8% (6 cases) in 3 days. The cumulative rate of clinical symptom improvement was 84.7% (182 cases) in 35 days. The clinical symptoms of all the children were improved. Conclusion the improvement time of clinical symptoms of children with influenza is earlier than the time of disappearance of antigens, and it is safe to return to school after 710 days of onset and 100% of influenza virus antigens turn negative.
【作者单位】： 湖南省人民医院儿童医学中心/湖南省师范大学第一附属医院;
【分类号】：R725.1
本文编号：2197420
[Abstract]:Objective to dynamically monitor influenza virus antigen in children with influenza by immunofluorescence antigen detection technique, and to observe the time of negative change of antigen and the time of disappearance of clinical symptoms, and the relationship between them. Methods from March to April 2016, 1 063 cases of suspected influenza in Hunan Provincial people's Hospital were tested with influenza A and B virus antigen test kit (immunofluorescence method), and those who were positive were treated with oseltamivir antiviral therapy. The patients were ordered to check the influenza virus antigen within 5 days after the onset of the disease and within 5 days and 7 days after the onset of influenza virus antigen. Results among 1 063 suspected influenza cases, 560 cases (52.68%) were detected by influenza virus. 215 cases of influenza virus positive children were followed up. The negative conversion rate of influenza virus antigen within 5 days was 9.8% (21 cases). The cumulative negative conversion rate was 32.1% (69 cases) within 7 days, 98.1% (211 cases) in 10 days, and 2.8% (6 cases) in 3 days. The cumulative rate of clinical symptom improvement was 84.7% (182 cases) in 35 days. The clinical symptoms of all the children were improved. Conclusion the improvement time of clinical symptoms of children with influenza is earlier than the time of disappearance of antigens, and it is safe to return to school after 710 days of onset and 100% of influenza virus antigens turn negative.
【作者单位】： 湖南省人民医院儿童医学中心/湖南省师范大学第一附属医院;
【分类号】：R725.1
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