西地那非在新生儿持续性肺动脉高压中的应用效果及安全性分析

发布时间：2018-08-22 17:18

【摘要】：目的探讨西地那非治疗新生儿持续性肺动脉高压的疗效和安全性。方法纳入2014年1月至2016年6月该院收治的新生儿肺动脉高压患儿,根据西地那非治疗剂量分成3组:A组0.5mg/kg,B组1mg/kg,C组2mg/kg,每6小时1次,均通过鼻饲管注入。结果共纳入60例患儿,每组患儿20例,其中A组患儿平均胎龄(36.1±4.1)周(男9例,女11例),B组患儿平均胎龄(35.8±3.9)周(男12例,女8例),C组患儿平均胎龄(37.2±4.3)周(男、女各10例)。3组患儿经给予西地那非治疗后平均肺动脉压均显著下降、氧饱和度与氧分压均显著升高,差异有统计学意义(P0.01);西地那非治疗新生儿肺动脉高压具有剂量依赖性,剂量越高疗效越显著,B组与C组均较A组临床指标恢复更好、恢复时间更短,但是剂量越高不良反应越多,差异有统计学意义(P0.05)。结论西地那非是治疗新生儿持续性肺动脉高压的有效药物,但需注意高剂量时的不良反应。
[Abstract]:Objective to evaluate the efficacy and safety of sildenafil in the treatment of neonatal persistent pulmonary hypertension. Methods from January 2014 to June 2016, neonates with pulmonary hypertension were divided into three groups according to the dosage of sildenafil: group A, 0.5 mg / kg, group B, group 1 mg / kg, group C, 2 mg / kg, once every 6 hours, all injected through nasal feeding tube. Results the average gestational age of group A was (36.1 卤4.1) weeks (male 9, female 11). The average gestational age of group B was (35.8 卤3.9) weeks (male 12, female 8). The mean gestational age of group C was (37.2 卤4.3) weeks (male). After treatment with sildenafil, the mean pulmonary artery pressure decreased significantly, oxygen saturation and oxygen partial pressure increased significantly (P0.01), and the effect of sildenafil on neonatal pulmonary hypertension was dose-dependent. The higher the dose, the more significant the recovery of clinical indexes and the shorter recovery time were in group B and C, but the higher the dose, the more adverse reactions, the difference was statistically significant (P0.05). Conclusion Sildenafil is an effective drug in the treatment of persistent pulmonary hypertension in neonates.
【作者单位】：安徽医科大学第二附属医院儿科;
【分类号】：R722.19

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