奥曲肽注射液治疗坏死性小肠结肠炎新生儿的临床研究

发布时间：2018-08-24 08:46

【摘要】：目的观察奥曲肽注射液联合水解奶粉对坏死性小肠结肠炎新生儿营养状态、免疫功能的影响。方法 90例坏死性小肠结肠炎新生患儿分为试验组和对照组,各45例。所有患儿均用30 g·kg~(-1)的奥曲肽注射液进行治疗,对照组喂养常规配方奶粉,试验组喂养水解配方奶粉,根据患儿的实际情况进行哺乳,连续治疗1周。治疗后,比较2组患儿的营养状态(血清白蛋白、血清前蛋白)、免疫功能(CD_4~+细胞、CD_8~+细胞、免疫球蛋白G、免疫球蛋白A、免疫球蛋白M)及胃肠道激素的变化,并比较2组患儿的临床疗效。结果治疗后,试验组患儿的总有效率为93.33%(42/45例),对照组为77.78%(35/45例,P0.05)。治疗后,试验组患儿的血清白蛋白为(41.51±5.59)g·L~(-1),血清前蛋白含量为(112.37±15.35)g·L~(-1);对照组血清白蛋白为(32.59±4.42)g·L~(-1),血清前蛋白含量为(103.24±13.67)g·L~(-1)(P0.05)。治疗后,试验组胃泌素为(292.51±35.87)pg·mL~(-1),胃动素为(121.81±16.38)pg·mL~(-1);对照组胃泌素为(231.41±29.15)pg·mL~(-1),胃动素为(90.47±11.36)pg·mL~(-1)(P0.05)。治疗后,试验组CD_4~+、CD_8~+为(28.30±2.62)%,(21.90±2.45)%;对照组为(32.03±2.13)%,(27.80±2.54)%(P0.05)。试验组免疫球蛋白G、免疫球蛋白A、免疫球蛋白M分别为(13.16±1.03),(2.94±0.23),(1.46±0.15)mg·dL~(-1),对照组分别为(11.13±0.41),(1.97±0.16),(1.22±0.25)mg·dL~(-1)(P0.05)。2组患儿治疗过程中均没有发生药物不良反应。结论奥曲肽联合水解奶粉喂养新生儿坏死性小肠结肠炎,能明显的改善患儿的营养状态和免疫功能,提高患儿的肠胃激素含量,提高治疗效果。
[Abstract]:Objective To observe the effect of octreotide injection combined with hydrolyzed milk powder on nutritional status and immune function of neonates with necrotizing enterocolitis.Methods 90 neonates with necrotizing enterocolitis were divided into experimental group and control group, 45 cases in each group. After treatment, the nutritional status (serum albumin, serum prealbumin), immune function (CD_4~+ cells, CD_8~+ cells, immunoglobulin G, immunoglobulin A, immunoglobulin M) and gastrointestinal hormones were compared between the two groups. Results After treatment, the total effective rate was 93.33% (42/45 cases) in the experimental group and 77.78% (35/45 cases, P 0.05) in the control group. After treatment, the serum albumin of the experimental group was (41.51 (5.59) g (-1), the serum prealbumin content was (112.37 (15.35) g (-1), the serum albumin of the control group was (32.59 (4.42) g (-1), and the serum albumin of the control group After treatment, the gastrin was (292.51 [(35.87) PG mg mL ~(-1) and motilin was (121.81 [(16.81 [16.38) PG mL ~ (-1); the gastrin was (231.41 [29.15) PG mL ~ (-1) in control group (231.41 [(29.15) PG ~ (-1), motilin was (90.47 [11.36) PG mL ~ (-1)(90.47 [(90.47 [11.36) PG [11.36) PG mL ~ (-1)(P 0.05). After treatment, the levels of motilin were (121, 121.81(28.30 (+ 2.62)%, (21.90)%. Immunoglobulin G, immunoglobulin A, and immunoglobulin M were (13.16 (+ 1.03), (2.94 (+ 0.23), (1.46 (+ 0.15) mg (- 1) respectively in the experimental group and (11.13 (+ 0.41), (1.97 (+ 0.16), (1.22 (+ 0.25) mg (- 1) (P 0.05)) in the control group. Conclusion Octreotide combined with hydrolyzed milk powder can obviously improve the nutritional status and immune function of neonates with necrotizing enterocolitis, increase the content of gastrointestinal hormones and improve the therapeutic effect.
【作者单位】：泰顺人民医院儿科;温州市人民医院新生儿科;瑞安市人民医院儿科;
【基金】：温州市科技计划基金资助项目(2015A11)
【分类号】：R722.19

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