LISA技术治疗新生儿呼吸窘迫综合征有效性的系统评价
发布时间：2018-08-24 09:08
【摘要】：目的评价经微管气管内注入肺泡表面活性剂(LISA)联合持续气道正压通气(CPAP)序贯技术治疗新生儿呼吸窘迫综合征(RDS)的有效性。方法检索PubMed、EMBASE、Cochrane图书馆、相关期刊论文、万方数据库、维普中文科技期刊数据库及中国生物医学文献数据库,查找所有LISA联合CPAP治疗RDS的随机对照试验。采用RevMan 5.2软件进行meta分析,分别比较胎龄34周罹患RDS的早产儿中,LISA组和对照组的病死率以及支气管肺发育不良(BPD)、早产儿视网膜病(ROP)、脑室内出血(IVH)、脑室周围白质软化(PVL)等并发症发生率的差异。结果共纳入5篇随机对照研究,含759例患儿。与对照组相比,LISA组患儿机械通气比率低(RR:0.32,95%CI:0.13~0.82);BPD发生率低(RR:0.61,95%CI:0.42~0.88);但两组患儿病死率、ROP、IVH、气胸及PVL发生率差异无统计学意义(P均0.05)。结论 LISA技术治疗新生儿呼吸窘迫综合征可明显降低机械通气及BPD发生率,但对其他并发症发生率及病死率无影响。
[Abstract]:Objective to evaluate the efficacy of intratracheal instillation of alveolar surfactant (LISA) with continuous positive airway pressure (CPAP) in the treatment of neonatal respiratory distress syndrome (RDS). Methods PubMed,EMBASE,Cochrane library, full text database of Chinese periodicals, Wanfang database, Weipu Chinese science and technology journal database and Chinese biomedical literature database were searched for all randomized controlled trials of LISA combined with CPAP therapy for RDS. Meta analysis was carried out with RevMan 5.2 software. The mortality of premature infants with RDS at 34 weeks of gestational age and the incidence of complications such as (ROP), intraventricular hemorrhage in (BPD), premature infants with bronchopulmonary dysplasia and (PVL) in periventricular leukomalacia were compared. Results A total of 5 randomized controlled studies were conducted, including 759 children. Compared with the control group, the incidence of mechanical ventilation (RR:0.32,95%CI:0.13~0.82) and bpd (RR:0.61,95%CI:0.42~0.88) was lower, but there was no significant difference in mortality, pneumothorax and PVL between the two groups (P < 0. 05). Conclusion LISA can significantly reduce the incidence of mechanical ventilation and BPD, but has no effect on other complications and mortality.
【作者单位】： 深圳市宝安区妇幼保健院新生儿科;台湾中国医药大学儿科学院新生儿科;
【分类号】：R722.1
本文编号：2200315
[Abstract]:Objective to evaluate the efficacy of intratracheal instillation of alveolar surfactant (LISA) with continuous positive airway pressure (CPAP) in the treatment of neonatal respiratory distress syndrome (RDS). Methods PubMed,EMBASE,Cochrane library, full text database of Chinese periodicals, Wanfang database, Weipu Chinese science and technology journal database and Chinese biomedical literature database were searched for all randomized controlled trials of LISA combined with CPAP therapy for RDS. Meta analysis was carried out with RevMan 5.2 software. The mortality of premature infants with RDS at 34 weeks of gestational age and the incidence of complications such as (ROP), intraventricular hemorrhage in (BPD), premature infants with bronchopulmonary dysplasia and (PVL) in periventricular leukomalacia were compared. Results A total of 5 randomized controlled studies were conducted, including 759 children. Compared with the control group, the incidence of mechanical ventilation (RR:0.32,95%CI:0.13~0.82) and bpd (RR:0.61,95%CI:0.42~0.88) was lower, but there was no significant difference in mortality, pneumothorax and PVL between the two groups (P < 0. 05). Conclusion LISA can significantly reduce the incidence of mechanical ventilation and BPD, but has no effect on other complications and mortality.
【作者单位】： 深圳市宝安区妇幼保健院新生儿科;台湾中国医药大学儿科学院新生儿科;
【分类号】：R722.1
【相似文献】
相关期刊论文 前1条
1 许志强;LISA(利萨)分立任选式多参数全自动生化分析仪故障探讨[J];医疗装备;2000年01期
，本文编号：2200315
本文链接：https://www.wllwen.com/yixuelunwen/eklw/2200315.html
最近更新
教材专著
