呼吸道感染患儿MP与INFB水平的诊断价值分析

发布时间：2018-08-24 10:30

【摘要】：目的探究儿童呼吸道感染患者的肺炎支原体(MP)、乙型流感病毒(INFB)阳性检出情况,为儿童呼吸道感染的临床诊治提供参考。方法选取医院2015年4月-2016年8月采用间接免疫荧光法对300例儿童呼吸道感染患者的血清样本进行MP、INFB、Q热立克抗体(COX)、嗜肺军团菌1型(LP1)、肺炎衣原体(CP)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、副流感病毒(PIVs,1型、2型、3型)共计9种病原体的IgM抗体检测,对呼吸道感染患儿单一病原体感染和多种病原体混合感染情况进行观察分析,并从季节、患儿年龄分段入手,对比不同季节、不同年龄段患儿单一MP感染、单一INFB感染及MP+INFB感染的发生比例。结果 300例呼吸道感染患儿当中共检出病原体阳性感染136例,阳性率45.33%;检出病原体以MP、INFB为主,其中MP阳性有104例,阳性率为34.67%,占总阳性例数的76.47%;INFB阳性有47例,阳性率为15.67%,占总阳性例数的34.56%;混合感染共计45例,其中以MP+INFB感染最为常见,占阳性病例的17.65%;患儿在春冬季出现单一MP感染、单一INFB感染以及MP+INFB混合感染的比例明显大于夏秋季,差异比较有统计学意义(P0.05);婴儿组患儿出现单一MP感染、单一INFB感染以及MP+INFB混合感染的比例分别为22.03%、10.53%、12.50%,其感染构成比与幼儿组、儿童组两组患儿比较存在显著差异(P0.05),而幼儿组、儿童组两组之间比较并无明显差异。结论儿童呼吸道感染以MP、INFB感染为主要病原体,MP容易与其他病原体发生混合感染;MP、INFB感染的发病年龄多见于1岁以上,且与季节密切相关,以春冬季为高发季节;通过检测呼吸道常见9种病原体能够明确呼吸道感染患儿的病原体感染情况,为临床合理诊治提供参考。
[Abstract]:Objective to investigate the positive detection of mycoplasma pneumoniae (MP), B influenza virus (INFB) in children with respiratory tract infection and to provide reference for clinical diagnosis and treatment of respiratory tract infection in children. Methods from April 2015 to August 2016, the serum samples of 300 children with respiratory tract infection were collected by indirect immunofluorescence assay for MP,INFB,Q fever antibody (COX), Legionella pneumoniae type 1 (LP1), chlamydia pneumoniae (CP), adenovirus (ADV), in respiratory tract. Syncytial virus (RSV), influenza A virus (INFA), parainfluenza virus (PIVs,1 type 2 serotype 3) a total of 9 pathogens of IgM antibody detection. The single pathogen infection and mixed infection of multiple pathogens in children with respiratory tract infection were observed and analyzed. The single MP infection was compared between different seasons and different ages. Proportion of single INFB infection and MP INFB infection. Results among the 300 cases of respiratory tract infection, 136 cases were positive for pathogens, the positive rate was 45.33, and the main pathogen was MP,INFB, of which 104 cases were MP positive, the positive rate was 34.67 and the positive rate was 76.4747% of the total positive cases. The positive rate was 15.67, accounting for 34.56% of the total positive cases, and 45 cases of mixed infection were found, among which MP INFB infection was the most common, accounting for 17.65% of the positive cases. A single MP infection occurred in the spring and winter. The proportion of single INFB infection and MP INFB mixed infection was significantly higher than that of summer and autumn, the difference was statistically significant (P0.05). The proportion of single INFB infection and MP INFB mixed infection were 22.0310.53 and 12.50, respectively. There was significant difference between the two groups (P0.05), but there was no significant difference between the two groups. Conclusion MP,INFB infection is the main pathogen of respiratory tract infection in children. The infection of MP is easily mixed with other pathogens. The age of infection is more than 1 year old, which is closely related to the season, and the high incidence season is in spring and winter. The detection of 9 common pathogens in respiratory tract can identify the pathogen infection in children with respiratory tract infection and provide reference for clinical diagnosis and treatment.
【作者单位】：石嘴山市第一人民医院儿科;
【基金】：宁夏自然科学基金资助项目(NZ0790)
【分类号】：R446.6;R725.6

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