儿童化脓性脑膜炎病原菌及耐药性与醒脑静治疗效果研究

发布时间：2018-08-25 10:58

【摘要】：目的研究儿童化脓性脑膜炎病原菌、耐药性及醒脑静在该类患儿中的治疗效果,为儿童化脓性脑膜炎的诊断与治疗提供依据。方法选取2015年5月-2016年5月医院收治的化脓性脑膜炎患儿66例,进行病原菌及其耐药性检测,将66例患儿随机分为两组,对照组33例患儿进行常规治疗,观察组33例患儿则在对照组的基础上加用醒脑静进行治疗,统计并比较两组患儿治疗总有效率。结果 66例化脓性脑膜炎患儿共检出66株病原菌,其中肺炎链球菌检出率最高占36.36%,明显高于其他病原菌检出率,差异有统计学意义(P0.05);而常见病原菌对左氧氟沙星、哌拉西林及头孢唑林的耐药率相对较高,明显高于对其他药物的耐药率;治疗总有效率观察组患儿为90.91%,明显高于对照组患儿69.70%,差异有统计学意义(P0.05)。结论儿童化脓性脑膜炎病原菌主要以肺炎链球菌为主,其耐药性较为明显,同时醒脑静在此类患儿中的应用效果较好。
[Abstract]:Objective to study the effect of pathogenic bacteria, drug resistance and Xingnaojing on suppurative meningitis in children, and to provide evidence for diagnosis and treatment of suppurative meningitis in children. Methods 66 children with suppurative meningitis admitted in our hospital from May 2015 to May 2016 were selected and tested for pathogens and drug resistance. 66 cases were randomly divided into two groups. 33 cases in control group were treated with routine therapy. 33 children in the observation group were treated with Xingnaojing on the basis of the control group, and the total effective rate was compared between the two groups. Results 66 strains of pathogenic bacteria were detected in 66 children with suppurative meningitis, among which the highest detection rate of Streptococcus pneumoniae was 36.36, which was significantly higher than that of other pathogens (P0.05), while the common pathogenic bacteria to levofloxacin, The drug resistance rate of piperacillin and cefazolin was higher than that of other drugs, and the total effective rate of observation group was 90.91, which was significantly higher than that of control group (P 0.05). Conclusion Streptococcus pneumoniae is the main pathogen of suppurative meningitis in children, and the drug resistance of Streptococcus pneumoniae is obvious.
【作者单位】：新乡市妇幼保健院儿童康复中心;
【分类号】：R725.1

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