家养宠物暴露对非哮喘儿童肺功能的影响

发布时间：2018-08-30 07:30

【摘要】：目的:探讨家养宠物暴露对非哮喘儿童肺功能的影响,为预防儿童肺功能损伤提供科学依据。方法:采用横断面调查的方法,在辽宁省7个城市的24个行政区,整群随机抽取1~2所初中和小学,进行ATS问卷调查,并采用便携式肺功能呼吸仪测定肺功能,包括第1 s用力呼气量(FEV1),用力肺活量(FVC),最大呼气中期流量(MMEF)和呼气峰流量(PEF)。结果:本研究共调查了7~14岁的非哮喘儿童青少年6 280例,其中男孩3 107例,占49.47%。儿童肺功能的FVC、FEV1、PEF和MMEF指标平均分别为(2.63±0.75)L、(2.47±0.70)L、(4.80±1.42)L/s和(3.37±1.05)L/s。在调整了性别、年龄、BMI等混杂因素后,在出生后前两年曾暴露于家养宠物与FVC肺功能指标损伤显著相关(a OR=1.30;95%CI:1.01~1.67),且目前暴露于家养宠物与FVC(a OR=1.32;95%CI:1.09~1.61)、FEV1(a OR=1.47;95%CI:1.19~1.83)、PEF(a OR=1.48;95%CI:1.16~1.88)和MMEF(a OR=1.35;95%CI:1.09~1.66)4个肺功能指标损伤均显著相关。而出生前曾暴露于家养宠物与肺损伤各指标均不相关。结论:家养宠物对非哮喘儿童的肺功能有损害作用,可降低FVC、FEV1、PEF和MMEF等指标。
[Abstract]:Objective: to investigate the effects of domestic pet exposure on lung function in non-asthmatic children and to provide scientific basis for prevention of lung function injury in children. Methods: ATS questionnaire was conducted in 1 middle school and 2 primary schools in 24 administrative districts of 7 cities in Liaoning Province by cross-sectional investigation. Pulmonary function was measured by portable respiratory apparatus. Including 1 s forced expiratory volume (FEV1), forced vital capacity (FVC), maximum mid expiratory flow (MMEF) and peak expiratory flow (PEF).) Results: a total of 6 280 non-asthmatic children and adolescents aged 7 to 14 years were investigated in this study, including 3 107 boys (49. 47%). The mean FVC,FEV1,PEF and MMEF indexes of pulmonary function in children were (2.63 卤0.75) L, (2.47 卤0.70) L, (4.80 卤1.42) L / s and (3.37 卤1.05) L / s, respectively. After adjusting for gender, age, BMI and other confounding factors, Two years after birth, there was a significant correlation between exposure to domestic pets and FVC lung function damage (a OR=1.30;95%CI:1.01~1.67), and at present, FEV1 (a OR=1.47;95%CI:1.19~1.83) PEF (a OR=1.48;95%CI:1.16~1.88) and MMEF (a OR=1.35;95%CI:1.09~1.66) were significantly correlated with FVC (a OR=1.32;95%CI:1.09~1.61. There was no correlation between exposure to domestic pets before birth and lung injury. Conclusion: domestic pets can damage lung function of non-asthmatic children and can reduce FVC,FEV1,PEF and MMEF.
【作者单位】：广州市中小学卫生健康促进中心;中山大学公共卫生学院预防医学系;
【基金】：国家自然科学基金(编号:81472936) 广东省国际合作项目(编号:2014A050503027)
【分类号】：R725.6

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