家养宠物暴露对非哮喘儿童肺功能的影响

发布时间：2018-08-30 07:30

【摘要】：目的:探讨家养宠物暴露对非哮喘儿童肺功能的影响,为预防儿童肺功能损伤提供科学依据。方法:采用横断面调查的方法,在辽宁省7个城市的24个行政区,整群随机抽取1~2所初中和小学,进行ATS问卷调查,并采用便携式肺功能呼吸仪测定肺功能,包括第1 s用力呼气量(FEV1),用力肺活量(FVC),最大呼气中期流量(MMEF)和呼气峰流量(PEF)。结果:本研究共调查了7~14岁的非哮喘儿童青少年6 280例,其中男孩3 107例,占49.47%。儿童肺功能的FVC、FEV1、PEF和MMEF指标平均分别为(2.63±0.75)L、(2.47±0.70)L、(4.80±1.42)L/s和(3.37±1.05)L/s。在调整了性别、年龄、BMI等混杂因素后,在出生后前两年曾暴露于家养宠物与FVC肺功能指标损伤显著相关(a OR=1.30;95%CI:1.01~1.67),且目前暴露于家养宠物与FVC(a OR=1.32;95%CI:1.09~1.61)、FEV1(a OR=1.47;95%CI:1.19~1.83)、PEF(a OR=1.48;95%CI:1.16~1.88)和MMEF(a OR=1.35;95%CI:1.09~1.66)4个肺功能指标损伤均显著相关。而出生前曾暴露于家养宠物与肺损伤各指标均不相关。结论:家养宠物对非哮喘儿童的肺功能有损害作用,可降低FVC、FEV1、PEF和MMEF等指标。
[Abstract]:Objective: To explore the effect of domestic pet exposure on pulmonary function in non-asthmatic children and provide scientific basis for preventing pulmonary function injury in children. Methods: A cross-sectional survey was conducted in 24 administrative districts of 7 cities in Liaoning Province. One to two junior middle schools and primary schools were randomly sampled for ATS questionnaires and measured by portable pulmonary function respirator. Pulmonary function, including forced expiratory volume (FEV1), forced vital capacity (FVC), maximal mid-expiratory flow (MMEF) and peak expiratory flow (PEF), was investigated in 6 280 non-asthmatic children and adolescents aged 7 to 14 years, of whom 3 107 (49.47%) were boys. After adjusting for sex, age, BMI and other confounding factors, exposure to domestic pets in the first two years after birth was significantly associated with FVC pulmonary function injury (a OR = 1.30; 95% CI: 1.01-1.67), and is currently exposed to domestic pets and FVC (a OR = 1.32; 95% CI: 1.09-1.61), FEV1 (a = 1.47; 95% CI: 1.83), respectively. PEF (a OR = 1.48; 95% CI: 1.16-1.88) and MEF (a OR = 1.35; 95% CI: 1.09-1.66) were significantly correlated with lung injury, while exposure to domestic pets before birth was not correlated with lung injury.
【作者单位】：广州市中小学卫生健康促进中心;中山大学公共卫生学院预防医学系;
【基金】：国家自然科学基金(编号:81472936) 广东省国际合作项目(编号:2014A050503027)
【分类号】：R725.6

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