小儿气虚血瘀型反复呼吸道感染证治与儿童气虚质相关性研究探讨

发布时间：2018-09-17 13:47

【摘要】：反复呼吸道感染(RRTI)是儿科的常见疾病,是指在单位时间内上、下呼吸道感染发作超过规定次数的一种临床综合征。该病如果反复发作,病程迁延,将严重影响小儿的生长发育和身心健康。传统中医认为反复呼吸道感染多因小儿正气不足而致。现代医学研究证实,RRTI是多种因素综合的结果,其中免疫、微量元素等因素是近年来主要研究对象,并与小儿体质类型密切相关。导师王俊宏教授自拟益气活血运脾方治疗气虚血瘀型小儿反复呼吸道感染取得了很好的疗效。论文分为文献综述和临床研究两部分。文献综述首先介绍了古代和近代医家对于小儿体质的认识及进展；其次论述了反复呼吸道感染的中西医研究治疗进展。临床研究部分对符合纳入标准的62例病例进行临床研究,包括数据采集、统计、结果分析与讨论等。目的：观察益气活血运脾方对治疗RRTI的临床疗效；对RRTI患儿进行中医体质分类,探讨RRTI患儿体质类型与其一般情况的关系；并检测RRTI气虚血瘀型患儿的免疫球蛋白、T淋巴细胞亚群、微量元素、血红蛋白等实验室指标,旨在探讨RRTI与免疫、微量元素等的相关性。方法：对符合纳入标准的62例RRTI病例进行中医体质分类(分为气虚质和其他质),观察两种体质类型与性别、喂养史、母亲分娩方式、过敏史的相关性；将62例随机分为治疗组(32例)和对照组(30例),治疗组应用益气活血运脾方治疗,对照组应用玉屏风散治疗,观察治疗前后患儿症状以及实验室检查指标,所得数据用SPSS17.0统计软件进行统计学分析处理。结果： 1. RRTI患儿以气虚体质为多(56.5%)； 2.气虚质与性别、喂养史、母亲分娩方式、过敏史等有一定相关性； 3. RRTI患儿存在细胞免疫、体液免疫及微量元素的紊乱：I gG IgA、CD3、CD4、CD4/CD8下降,微量元素Fe、Zn含量较低。 4.益气活血运脾方在改善RRTI患儿的主要、次要症状方面有显著作用(P0.05),能显著提高患儿免疫功能,总有效率为96.88%。
[Abstract]:Recurrent respiratory tract infection (RRTI) is a common disease in pediatrics. If the disease is repeated and the disease is prolonged, it will seriously affect the growth and physical and mental health of children. Traditional Chinese medicine believes that recurrent respiratory tract infection is caused by deficiency of children's qi. Modern medical studies have proved that RRTI is the result of many factors, of which immunity and trace elements are the main research objects in recent years, and are closely related to the physical type of children. Professor Wang Junhong, a tutor, has made a good curative effect on recurrent respiratory tract infection in children with Qi deficiency and blood stasis. The paper is divided into two parts: literature review and clinical research. The literature review first introduces the understanding and progress of ancient and modern physicians on children's constitution, and then discusses the progress of TCM and western medicine in the treatment of recurrent respiratory tract infection. In the clinical study, 62 cases were studied, including data collection, statistics, result analysis and discussion. Objective: to observe the clinical efficacy of Yiqi Huoxue Yunpi recipe in treating RRTI, to classify TCM constitution of RRTI children, and to explore the relationship between physical types and general conditions of RRTI children. The laboratory indexes of immunoglobulin T lymphocyte subsets, trace elements and hemoglobin in children with RRTI syndrome of qi deficiency and blood stasis were detected. The purpose of this study was to explore the correlation between RRTI and immunity and trace elements. Methods: 62 cases of RRTI were divided into Qi-deficiency and other types, and the correlation between the two types and sex, feeding history, mother's delivery mode and allergic history was observed. 62 cases were randomly divided into treatment group (32 cases) and control group (30 cases). The treatment group was treated with Yiqi Huoxue Yunpi recipe and the control group was treated with Yupingfeng powder. The data were analyzed by SPSS17.0 software. Results: 1. Qi-deficiency constitution was more common in children with RRTI (56.5%). Qi-deficiency was related to sex, feeding history, mother's delivery mode, allergic history, etc. The levels of cellular immunity, humoral immunity and trace elements in children with RRTI were disordered: I gG IgA,CD3,CD4,CD4/CD8 decreased, and trace element Fe,Zn content was lower. 4. 4%. Yiqi Huoxue Yunpi prescription in improving the main and secondary symptoms of RRTI has a significant role (P0.05) can significantly improve the immune function of the children the total effective rate is 96.8888.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272

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