不同HAART方案对HIV合并HCV感染患儿肝功能和HIV载量的影响
发布时间：2018-10-13 12:51
【摘要】：目的探讨高效抗逆转录病毒治疗(HAART)不同治疗方案对人类免疫缺陷病毒(HIV)合并丙型肝炎病毒(HCV)感染患儿肝功能、HIV载量、CD4~+T细胞的影响。方法 40例患者分为齐多夫定(AZT)+拉米夫定(3TC)+奈韦拉平(NVP)联合组13例(A组),AZT+3TC+依非韦伦(EFV)联合组16例(B组),司他夫定(D4T)+3TC+EFV治疗组5例(C组),D4T+3TC+NVP治疗组6例(D组)。检测比较4组治疗前后肝功能、HIV载量、CD4~+T细胞。结果 HAART治疗前肝功能异常8例(20%),均为1级肝损害。4组治疗后A、B组ALT、AST上升(P0.01),C组治疗后AST上升(P0.01)。HAART治疗后各组CD4~+T细胞明显升高(P0.01),HIV-RNA病毒载量明显减低(P0.01)。治疗前后HCV-RNA载量变化差异无统计学意义(P0.05)。结论 HIV合并HCV感染患儿HAART不同治疗方案可增加肝损害,但对HAART治疗效果影响有限。
[Abstract]:Objective to investigate the effects of different antiretrovirals on liver function, HIV load and CD4~ T cells in children with hepatitis C virus (HCV) infection and (HIV) infection with human immunodeficiency virus (HIV). Methods Forty patients were divided into three groups: group A (group A, n = 16), group B (n = 16), group D _ 4T (n = 5) treated with 3TC EFV, group D _ 4T, group D _ 4T (n = 6). Liver function, HIV load and CD4~ T cell were measured before and after treatment. Results there were 8 cases (20%) with abnormal liver function before HAART treatment, all of which were grade 1 liver damage. After treatment, ALT,AST in group A and B was increased in group A (P 0.01), C group) (AST increased significantly after treatment with P0.01). HAART (P0.01). HAART), and the viral load of HIV-RNA was significantly decreased (P0.01). There was no significant difference in HCV-RNA load before and after treatment (P0.05). Conclusion different treatment regimens of HAART can increase liver damage in children with HIV complicated with HCV infection, but the effect on HAART is limited.
【作者单位】： 衢州职业技术学院医学院;浙江大学医学院附属第一医院传染病诊治国家重点实验室;金华职业技术学院医学院;浙江大学医学院附属儿童医院内科;浙江省衢州市疾病预防控制中心艾滋病研究室;浙江省衢州市人民医院感染科;
【基金】：浙江省公益性技术应用研究计划项目(2014C33252) 衢州市科技计划项目(2013Y019)
【分类号】：R725.1
，
本文编号：2268700
[Abstract]:Objective to investigate the effects of different antiretrovirals on liver function, HIV load and CD4~ T cells in children with hepatitis C virus (HCV) infection and (HIV) infection with human immunodeficiency virus (HIV). Methods Forty patients were divided into three groups: group A (group A, n = 16), group B (n = 16), group D _ 4T (n = 5) treated with 3TC EFV, group D _ 4T, group D _ 4T (n = 6). Liver function, HIV load and CD4~ T cell were measured before and after treatment. Results there were 8 cases (20%) with abnormal liver function before HAART treatment, all of which were grade 1 liver damage. After treatment, ALT,AST in group A and B was increased in group A (P 0.01), C group) (AST increased significantly after treatment with P0.01). HAART (P0.01). HAART), and the viral load of HIV-RNA was significantly decreased (P0.01). There was no significant difference in HCV-RNA load before and after treatment (P0.05). Conclusion different treatment regimens of HAART can increase liver damage in children with HIV complicated with HCV infection, but the effect on HAART is limited.
【作者单位】： 衢州职业技术学院医学院;浙江大学医学院附属第一医院传染病诊治国家重点实验室;金华职业技术学院医学院;浙江大学医学院附属儿童医院内科;浙江省衢州市疾病预防控制中心艾滋病研究室;浙江省衢州市人民医院感染科;
【基金】：浙江省公益性技术应用研究计划项目(2014C33252) 衢州市科技计划项目(2013Y019)
【分类号】：R725.1
，
本文编号：2268700
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