儿童过敏性紫癜湿热内蕴证ET、CGRP的临床研究

发布时间：2018-10-17 22:38

【摘要】：目的:本研究旨在初步探讨ET、CGRP与过敏性紫癜(HSP)湿热内蕴证在病程、致病因素、发病季节及临床表现等方面的相关性,并观察其变化的特异性,从而为临床研究HSP提供新的思路。方法:抽取34例符合HSP湿热内蕴证标准的患儿及23例正常儿童血液,采用酶联免疫法,检测其血浆中ET、CGRP的浓度。运用SPSS数据分析系统,分析其与疾病的相关性。结果:1.HSP患儿血浆ET浓度高于正常儿童,血浆CGRP的浓度则低于正常儿童。2.病程1年以上患儿的血浆ET浓度高于6个月至1年组和6个月以内组,各组间的浓度差异有显著性;病程6个月以内组的血浆CGRP高于6个月至1年组和1年以上组,各组件的浓度差异有显著性。3.皮肤紫癜密集的患儿血浆ET浓度高于皮肤紫癜稀疏患儿,血浆CGRP的浓度则低。4.伴腹痛患儿血浆ET浓度高于无腹痛患儿,血浆CGRP的浓度则低。5.伴关节表现的患儿血浆ET浓度高于无关节表现患儿,血浆CGRP的浓度则低。6.发病季节、发病频次、病因等因素与血浆ET浓度及血浆CGRP浓度无相关性。结论:1.HSP患儿血浆ET浓度比正常儿童高,血浆CGRP的浓度则低。2.HSP湿热内蕴证患儿血浆ET水平与病程呈现正相关性,病情严重患儿血浆ET水平高;HSP湿热内蕴证患儿血浆CGRP水平与病程呈现负相关性,病情严重患儿血浆CGRP水平低。3.ET浓度越高CGRP浓度越低,说明两者可能存在拮抗性。
[Abstract]:Objective: to explore the correlation between ET,CGRP and (HSP) dampness and heat accumulation syndrome of Henoch-Schonlein purpura in the course of disease, pathogenic factors, onset season and clinical manifestations, and to observe the specificity of the changes, so as to provide a new idea for clinical study of HSP. Methods: blood samples from 34 children with HSP dampness and heat accumulation syndrome and 23 normal children were tested for the concentration of ET,CGRP in plasma by enzyme linked immunosorbent assay (Elisa). SPSS data analysis system was used to analyze the correlation between the disease and the disease. Results: the plasma ET concentration in 1.HSP children was higher than that in normal children, and the plasma CGRP concentration was lower than that in normal children. The plasma ET concentration of children with disease course more than 1 year was higher than that of 6 months to 1 year group and less than 6 months group, and there was significant difference among each group, and the plasma CGRP level of the disease course less than 6 months group was higher than that of 6 months to 1 year group and more than 1 year group. There was significant difference in the concentration of each component. 3. The concentration of plasma ET in children with dense skin purpura was higher than that in children with sparse skin purpura, and the concentration of plasma CGRP was 4. 4%. The concentration of plasma ET was higher in children with abdominal pain than that in children without abdominal pain, and the concentration of plasma CGRP was lower than that in children without abdominal pain. The concentration of plasma ET in children with joint manifestation was higher than that in children without joint manifestation, and the concentration of plasma CGRP was 6. 6%. There was no correlation between plasma ET concentration and plasma CGRP concentration, such as onset season, frequency, etiology and so on. Conclusion: the concentration of plasma ET in children with 1.HSP is higher than that in normal children, and the concentration of plasma CGRP is lower in children with 2.HSP damp-heat syndrome. There is a positive correlation between plasma ET level and course of disease in children with 2.HSP dampness and heat accumulation syndrome. There was a negative correlation between plasma CGRP level and course of disease in children with HSP dampness and heat accumulation syndrome. The higher the 3.ET concentration, the lower the CGRP level, which indicated that there might be antagonism between the plasma CGRP level and the course of disease.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R272

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