有消化道症状儿童全血微量元素、血清瘦素水平与幽门螺杆菌感染的关系研究

发布时间：2018-10-24 06:31

【摘要】：目的探讨儿童幽门螺杆菌(Hp)感染与全血微量元素、血清瘦素水平的关系,为临床治疗提供参考及进一步明确临床意义。方法 2011年5月-10月在中南大学湘雅二医院儿科门诊就诊的1-14岁儿童,选取具有上消化道症状(包括上腹痛或脐周痛、呕吐、食欲不振等)的儿童101例。其中男54例,女47例。通过酶联免疫吸附分析(ELISA)法测定Hp抗体,其中阳性者56例,阴性者45例。Hp阳性者中男29例,女27例,阴性者中男25例,女20例。通过火焰原子吸收法测定两组儿童全血微量元素(铜、锌、钙、镁、铁)的含量。通过ELISA法测定两组儿童血清瘦素水平。应用SPSS17.0统计软件分析两组儿童血微量元素、瘦素水平的变化。结果 1.Hp感染与年龄有关(P0.05)；2.Hp阳性组和Hp阴性组儿童性别比较无显著性差异(P0.05)；3.Hp阳性组和Hp阴性组儿童全血钙、镁、铜含量比较无显著差异性(P0.05),Hp阳性组锌、铁含量低于Hp阴性组,且差别具有统计学意义(P0.05)；4.Hp阳性组血清瘦素水平低于Hp阴性组,但差异无统计学意义(P0.05)；5.男性血清瘦素水平低于女性,差异无统计学意义(P0.05)。男性及女性儿童Hp阳性组与Hp阴性组血清瘦素水平间差异无统计学意义(P0.05)。结论 1.儿童幽门螺杆菌感染率随着年龄的增长而增加,与性别无明显相关性；2.幽门螺杆菌感染与儿童锌、铁缺乏相关,对幽门螺杆菌感染患儿应进行锌、铁元素测定,及时给予治疗,纠正锌、铁的不足,以减少由此引起的锌、铁缺乏对儿童生长发育的影响；3.幽门螺杆菌感染对血清瘦素水平没有影响；性别对血清瘦素水平没有影响。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (Hp) infection and serum leptin and trace elements in children, and to provide reference for clinical treatment and further clarify clinical significance. Methods from May to October 2011, 101 children with upper gastrointestinal symptoms (including upper abdominal pain or periumbilical pain, vomiting, loss of appetite, etc.) were selected from a pediatric outpatient clinic of Xiangya second Hospital of Central South University. There were 54 males and 47 females. (ELISA) assay was used to detect Hp antibody in 56 cases of positive and 45 cases of negative Hp. 29 cases were male, 27 cases were female, 25 cases were male and 20 cases were female. The contents of trace elements (Cu, Zn, Ca, mg, Fe) in whole blood of children in two groups were determined by flame atomic absorption spectrometry. Serum leptin levels were measured by ELISA method. The changes of serum trace elements and leptin levels in two groups were analyzed by SPSS17.0 software. Results 1.Hp infection was associated with age (P0.05), there was no significant difference in sex between 2.Hp positive group and Hp negative group (P0.05), and there was no significant difference in total blood calcium, magnesium and copper content between 3.Hp positive group and Hp negative group (P0.05). Iron content was lower than that of Hp negative group, and the difference was statistically significant (P0.05); the serum leptin level in 4.Hp positive group was lower than that in Hp negative group, but the difference was not statistically significant (P0.05). The serum leptin level of male was lower than that of female, the difference was not statistically significant (P0.05). There was no significant difference in serum leptin levels between male and female Hp positive group and Hp negative group (P0.05). Conclusion 1. The infection rate of Helicobacter pylori in children increased with age, and had no significant correlation with sex. 2. Helicobacter pylori infection is associated with zinc and iron deficiency in children. Children with Helicobacter pylori infection should be tested for zinc and iron, treated in time to correct the deficiency of zinc and iron in order to reduce the resulting zinc. The effect of iron deficiency on the growth and development of children. Helicobacter pylori infection had no effect on serum leptin level, while gender had no effect on serum leptin level.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.7

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