中药分期论治小儿咳嗽变异性哮喘（虚寒证）的临床研究
发布时间：2018-10-24 15:40
【摘要】：[目的]观察中药分期论治CVA的临床疗效,为中医药治疗CVA提供有效的方剂,为新药开发提供临床依据。 [方法]将60例CVA患儿随机分为治疗组和对照组,每组30例,治疗组采用中药分期论治(发作期使用温肺化痰饮,缓解期使用补肺健脾饮)治疗,疗程3月；对照组西药治疗(予孟鲁司特钠治疗3个月,发作期加用氨荼碱)。分别在治疗前、治疗2周、1月、2月和疗程结束(治疗3月后)时对疾病疗效和中医证候积分进行评估。 [结果]1.疾病疗效治疗组总有效率93.33%,对照组总有效率93.33%,两组差异无统计学意义(P＞0.05),两组疾病疗效相当。2.中医证候疗效治疗组总有效率96.67%,对照组总有效率90.00%,两组差异有显著统计学意义(P＜0.01),治疗组明显优于对照组。3.治疗组咳嗽平均消失时间6.13±1.87天,对照组咳嗽平均消失时间3.87±1.22天,差异有统计学意义(P＜0.05),对照组优于治疗组。4.治疗前后主证咳嗽积分比较：两组主证咳嗽积分与治疗后比较有显著统计学意义(P＜0.01),两组治疗后积分明显优于治疗前。两组治疗后比较无统计学意义(P＞0.05),两组治疗疗效相当。5.治疗前后次要症状的比较：两组次要症状积分与治疗前比较有统计学意义(P＜0.05),两组对次要症状均有改善作用。治疗后两组比较,在“自汗、神疲乏力、食少纳呆、大便异常、面白形寒”这5个方面有显著统计学意义(P＜0.01),治疗组症状改善明显优于对照组；在“揉眼、揉鼻喷嚏”这2项差异无统计学意义(P＞0.05),两组症状改善情况相当。6.两组治疗后各时间点与前一时间点比较：差异有统计学意义(P0.05),两组均能改善此病中医症状。7.中医总证候积分比较：两组治疗前后比较有显著统计学意义(P0.01),两组均能改善此病中医症状；治疗后两组中比较有显著统计学意义(P0.01),治疗组疗效明显优于对照组。 [结论]中药分期论治CVA主证咳嗽与西药组疗效相当,在治疗次要症状改善上效果明显优于西药组。
[Abstract]:Objective: to observe the clinical effect of CVA by stages of Chinese medicine, to provide effective prescription for CVA and to provide clinical basis for the development of new drugs. [methods] 60 children with CVA were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with traditional Chinese medicine by stages (Wenfei Huatan decoction in attack period, Bufei Jianpi decoction in remission period) for 3 months. The control group was treated with western medicine (montelukast sodium for 3 months, paroxysm plus ambromine). Before treatment, 2 weeks, 1 month, 2 months and the end of the course of treatment (after 3 months of treatment), the curative effect of the disease and the score of TCM syndromes were evaluated respectively. [result] 1. The total effective rate of the disease treatment group was 93.33 and that of the control group was 93.33. There was no significant difference between the two groups (P > 0.05). The total effective rate of TCM syndrome treatment group was 96.67 and that of control group was 90.00.The difference between the two groups was statistically significant (P < 0.01). The treatment group was significantly better than the control group (P < 0.01). The average time of cough disappearance was 6.13 卤1.87 days in the treatment group and 3.87 卤1.22 days in the control group (P < 0.05). Comparison of cough score before and after treatment: there was significant difference between the two groups before and after treatment (P < 0.01), and the score after treatment in two groups was significantly better than that before treatment. There was no significant difference between the two groups after treatment (P > 0.05). Comparison of secondary symptoms before and after treatment: the scores of secondary symptoms in the two groups were significantly higher than those before treatment (P < 0.05). After treatment, there were significant differences between the two groups in the five aspects of "self-sweating, fatigue, less food intake, abnormal stool, and cold face" (P < 0.01). The improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01), and the improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01). There was no significant difference between the two groups (P > 0.05), and the improvement of symptoms in the two groups was similar to that in the control group (6. 6%, P > 0. 05). Two groups after treatment at each time point compared with the previous time point: the difference was statistically significant (P0.05), the two groups can improve the symptoms of traditional Chinese medicine. Comparison of the total syndromes of TCM: there was significant difference between the two groups before and after treatment (P0.01), both groups could improve the TCM symptoms of the disease; after treatment, the two groups had significant statistical significance (P0.01), the curative effect of the treatment group was significantly better than that of the control group. [conclusion] the effect of traditional Chinese medicine in treating CVA cough by stages is similar to that in western medicine group, and it is better than that in western medicine group in the treatment of secondary symptoms.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272
本文编号：2291795
[Abstract]:Objective: to observe the clinical effect of CVA by stages of Chinese medicine, to provide effective prescription for CVA and to provide clinical basis for the development of new drugs. [methods] 60 children with CVA were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with traditional Chinese medicine by stages (Wenfei Huatan decoction in attack period, Bufei Jianpi decoction in remission period) for 3 months. The control group was treated with western medicine (montelukast sodium for 3 months, paroxysm plus ambromine). Before treatment, 2 weeks, 1 month, 2 months and the end of the course of treatment (after 3 months of treatment), the curative effect of the disease and the score of TCM syndromes were evaluated respectively. [result] 1. The total effective rate of the disease treatment group was 93.33 and that of the control group was 93.33. There was no significant difference between the two groups (P > 0.05). The total effective rate of TCM syndrome treatment group was 96.67 and that of control group was 90.00.The difference between the two groups was statistically significant (P < 0.01). The treatment group was significantly better than the control group (P < 0.01). The average time of cough disappearance was 6.13 卤1.87 days in the treatment group and 3.87 卤1.22 days in the control group (P < 0.05). Comparison of cough score before and after treatment: there was significant difference between the two groups before and after treatment (P < 0.01), and the score after treatment in two groups was significantly better than that before treatment. There was no significant difference between the two groups after treatment (P > 0.05). Comparison of secondary symptoms before and after treatment: the scores of secondary symptoms in the two groups were significantly higher than those before treatment (P < 0.05). After treatment, there were significant differences between the two groups in the five aspects of "self-sweating, fatigue, less food intake, abnormal stool, and cold face" (P < 0.01). The improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01), and the improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01). There was no significant difference between the two groups (P > 0.05), and the improvement of symptoms in the two groups was similar to that in the control group (6. 6%, P > 0. 05). Two groups after treatment at each time point compared with the previous time point: the difference was statistically significant (P0.05), the two groups can improve the symptoms of traditional Chinese medicine. Comparison of the total syndromes of TCM: there was significant difference between the two groups before and after treatment (P0.01), both groups could improve the TCM symptoms of the disease; after treatment, the two groups had significant statistical significance (P0.01), the curative effect of the treatment group was significantly better than that of the control group. [conclusion] the effect of traditional Chinese medicine in treating CVA cough by stages is similar to that in western medicine group, and it is better than that in western medicine group in the treatment of secondary symptoms.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272
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