解痉、化痰、扶正序贯治疗咳嗽变异性哮喘的疗效机制探讨
发布时间：2018-10-31 17:58
【摘要】：目的:探讨咳嗽变异性哮喘(CVA)的发病机理,及“解痉、化痰、扶正”序贯治疗对慢性气道炎症和气道重塑的影响及机制。方法:本次研究采用随机对照研究方法,收集厦门市中医院儿科门诊符合“风痰化热”型小儿咳嗽变异性哮喘患儿60例,年龄在2岁-14岁范围内,分为实验组和对照组,每组各30例。实验组予中药解痉方2周、消痰方2周、固本汤4周序贯治疗;对照组予布地奈德气雾剂外用,前期咳嗽明显时配合丙卡特罗口服治疗,总疗程8周。观察两组患儿治疗情况,记录并进行统计学处理。另两组患儿分别于治疗前后采静脉血2mL,肝素抗凝,-20℃冰箱保存,待样本试剂收集完全后寄往上海酶联生物科技有限公司进行试剂检测,均采用ELISA法。前期数据全权委托上海酶联生物科技有限公司处理,后期由本人进行数据整理及统计学处理,得出结论,撰写论文。结果:(1)两组治疗方法均能降低咳嗽症状积分及中医证候积分,但实验组咳嗽症状积分有效率为86.7%、中医证候积分有效率为83.3%;对照组咳嗽症状积分有效率为60%、中医证候积分有效率为56.7%。两组咳嗽证候积分比较P = 0.0250.05,说明两组疗效在统计学上有差别,可认为实验组的疗效高于对照组。两组中医证候积分比较P=0.0300.05,说明两组疗效在统计学上有差别,可认为实验组的疗效高于对照组。(2)两种治疗方法均对血清中IL-12、IL-4、TGF-β、TLR4含量有影响,实验组治疗后血清中TLR4、TGF-β含量均较治疗前明显降低,且实验组血清中TLR4、TGF-β含量治疗后均显著低于对照组;实验组治疗后血清中IL-12含量显著高于对照组、血清中IL-4含量在治疗后显著低于对照组,IL-12与IL-4出现负相关性。数据经统计学处理得知,实验组与对照组对血清中IL-12、IL-4、TGF-β、TLR4含量的影响,在统计学上均有差异。结论:两组治疗“风痰化热”型小儿咳嗽变异性哮喘均有确切疗效,实验组即解痉、化痰、扶正序贯治疗咳嗽变异性哮喘与对照组即布地奈德气雾剂联合丙卡特罗治疗咳嗽变异性哮喘比较具有统计学差异,因此中药序贯治疗“风痰化热”型小儿咳嗽变异性哮喘优于布地奈德气雾剂联合丙卡特罗治疗小儿咳嗽变异性哮喘,具有有效性、安全性及临床价值。
[Abstract]:Objective: to investigate the pathogenesis of cough variant asthma (CVA) and the effect and mechanism of sequential treatment of "spasmolysis, phlegm and tonifying" on chronic airway inflammation and airway remodeling. Methods: a randomized controlled study was used to collect 60 children with cough variant asthma, aged from 2 to 14 years old, in the pediatrics clinic of Xiamen traditional Chinese Medicine Hospital, who were divided into experimental group and control group, and 60 children with cough variant asthma of "wind-phlegm and heat" type were divided into experimental group and control group. There were 30 cases in each group. The experimental group was treated with traditional Chinese medicine for 2 weeks, Xiaotan decoction for 2 weeks, and Guben decoction for 4 weeks, while the control group was given budesonide aerosol for external use and oral treatment with Procaterol for 8 weeks when cough was obvious. Observation of the treatment of the two groups, records and statistical analysis. The other two groups were collected venous blood 2mL before and after treatment, heparin anticoagulant, -20 鈩，
本文编号：2303096
[Abstract]:Objective: to investigate the pathogenesis of cough variant asthma (CVA) and the effect and mechanism of sequential treatment of "spasmolysis, phlegm and tonifying" on chronic airway inflammation and airway remodeling. Methods: a randomized controlled study was used to collect 60 children with cough variant asthma, aged from 2 to 14 years old, in the pediatrics clinic of Xiamen traditional Chinese Medicine Hospital, who were divided into experimental group and control group, and 60 children with cough variant asthma of "wind-phlegm and heat" type were divided into experimental group and control group. There were 30 cases in each group. The experimental group was treated with traditional Chinese medicine for 2 weeks, Xiaotan decoction for 2 weeks, and Guben decoction for 4 weeks, while the control group was given budesonide aerosol for external use and oral treatment with Procaterol for 8 weeks when cough was obvious. Observation of the treatment of the two groups, records and statistical analysis. The other two groups were collected venous blood 2mL before and after treatment, heparin anticoagulant, -20 鈩，
本文编号：2303096
本文链接：https://www.wllwen.com/yixuelunwen/eklw/2303096.html
最近更新
教材专著
