615例住院早产儿出血的危险因素分析

发布时间：2018-11-05 20:04

【摘要】：目的分析早产儿出血的危险因素。方法通过收集整理2014年1月至2016年1月重庆医科大学附属儿童医院615例住院早产儿的临床资料(基本资料、围产因素、出血表现等)和相关实验室检查(凝血5项、血小板计数、白细胞计数),根据临床诊断是否有出血分为出血组和未出血组,先对两组患儿的临床资料及相关实验室检查进行单因素分析,然后对经过单因素分析有显著意义的自变量进行多因素Logistic回归分析。结果单因素分析发现两组患儿之间的胎龄、是否有窒息复苏史、白细胞计数、血小板计数和凝血5项中的凝血酶原时间和纤维蛋白原的差异有统计学意义(P0.05,P0.01)。多因素Logistics回归分析结果显示两组间胎龄、是否有窒息复苏史、血小板计数、白细胞、纤维蛋白原值差异有统计学意义(P0.05),胎龄、血小板计数和纤维蛋白原升高是保护因素,窒息复苏史、白细胞高是危险因素。结论早产儿胎龄低、有窒息复苏史、白细胞高、血小板计数和纤维蛋白原低均要警惕有出血的风险。
[Abstract]:Objective to analyze the risk factors of hemorrhage in premature infants. Methods from January 2014 to January 2016, the clinical data (basic data, perinatal factors, bleeding manifestations, etc.) and related laboratory tests (5 items of coagulation) of 615 premature infants in the Children's Hospital affiliated to Chongqing Medical University were collected and sorted. Platelet count, white blood cell count), according to the clinical diagnosis whether there is bleeding or not divided into bleeding group and no bleeding group, the two groups of children's clinical data and related laboratory tests were analyzed by single factor analysis. Then multivariate Logistic regression analysis was carried out on the independent variables with significant significance after univariate analysis. Results univariate analysis showed that there were significant differences in gestational age, history of asphyxia resuscitation, white blood cell count, platelet count and thrombin time and fibrinogen between the two groups (P0.05 / P0.01). Multivariate Logistics regression analysis showed that there were significant differences in fetal age, history of asphyxia resuscitation, platelet count, leukocyte, fibrinogen between the two groups (P0.05). Platelet count and fibrinogen increase were protective factors, asphyxia resuscitation history and high leukocyte were risk factors. Conclusion premature infants with low gestational age, history of asphyxia resuscitation, high white blood cell count, low platelet count and low fibrinogen should be alert to the risk of bleeding.
【作者单位】：重庆医科大学附属儿童医院麻醉科;重庆市急救医疗中心麻醉科;
【基金】：国家临床重点专科建设项目(2013544)~~
【分类号】：R722.6

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