静注人免疫球蛋白对累及神经系统手足口病患儿疗效与临床实验室检查相关性分析
发布时间：2018-11-07 11:03
【摘要】：目的研究观察通过静注人免疫球蛋白(IVIG)在累及神经系统的重症手足口病患儿的临床疗效。方法对2016年3月至2016年11月在本院住院并经IVIG治疗的累及神经系统手足口病重症患儿为研究对象。对患者进行静注人免疫球蛋白的注射治疗,并从病原菌(Ev71/Cox16/其他肠道病毒组)、炎性指标、脑脊液检查及免疫功能等方面进行汇总,综合比较IVIG疗效的差异。结果 85例患儿经IVIG治疗和预后:有效,70例,7 d内出院,治愈;效果不理想15例,有1例家长放弃而死亡(住院5 d),1例经3月康复治疗仍有肢体活动受限,余13例在出院3月内均已恢复。x~2检验显示:(1)IVIG疗效与病原菌具有相关性(x~2=7.930,P=0.005);(2)IVIG与患儿的炎性指标高低、脑脊液异常及免疫功能低下无关;(3)其他肠道病毒感染致的疗效不佳率的95%CI(0%,15%);99%CI(0%,20%);Ev71/Cox16感染致的效不佳率的95%CI(14.87%,38.98%);99%CI(11.05%,42.79%)。结论 IVIG疗效与致病菌有关,除Ev71/Cox16外其他肠道病毒感染致神经系统受累的重症手足口病患儿IVIG疗效较佳。
[Abstract]:Objective to observe the clinical effect of intravenous injection of human immunoglobulin (IVIG) in children with severe hand, foot and mouth disease (HFMD) involving the nervous system. Methods from March 2016 to November 2016, children with nervous system hand, foot and mouth disease who were hospitalized in our hospital and treated with IVIG were studied. The patients were treated with intravenous injection of human immunoglobulin and summarized from pathogenic bacteria (other enterovirus group of Ev71/Cox16/), inflammatory index, cerebrospinal fluid examination and immune function, and compared the difference of curative effect of IVIG. Results 85 cases were treated with IVIG, 70 cases were discharged within 7 days and cured. The results were not satisfactory in 15 cases. One parent gave up and died (5 d), in hospital and 1 case after 3 months rehabilitation treatment). The other 13 cases had recovered within 3 months of discharge. X2 test showed that: (1) there was a correlation between the efficacy of IVIG and the pathogenic bacteria (x2 + 7.930% P0. 005); (2) IVIG had no relation with inflammatory index, cerebrospinal fluid abnormality and immunosuppression, (3) 95%CI (0 15%) and 99%CI (0 20%) caused by other enterovirus infection. 95%CI (14.87%) and 99%CI (42.79%) caused by Ev71/Cox16 infection. Conclusion the curative effect of IVIG is related to pathogenic bacteria. The effect of IVIG in children with severe hand, foot and mouth disease caused by enterovirus infection other than Ev71/Cox16 is better.
【作者单位】： 吉林大学第一医院药学部;
【分类号】：R725.1
本文编号：2316152
[Abstract]:Objective to observe the clinical effect of intravenous injection of human immunoglobulin (IVIG) in children with severe hand, foot and mouth disease (HFMD) involving the nervous system. Methods from March 2016 to November 2016, children with nervous system hand, foot and mouth disease who were hospitalized in our hospital and treated with IVIG were studied. The patients were treated with intravenous injection of human immunoglobulin and summarized from pathogenic bacteria (other enterovirus group of Ev71/Cox16/), inflammatory index, cerebrospinal fluid examination and immune function, and compared the difference of curative effect of IVIG. Results 85 cases were treated with IVIG, 70 cases were discharged within 7 days and cured. The results were not satisfactory in 15 cases. One parent gave up and died (5 d), in hospital and 1 case after 3 months rehabilitation treatment). The other 13 cases had recovered within 3 months of discharge. X2 test showed that: (1) there was a correlation between the efficacy of IVIG and the pathogenic bacteria (x2 + 7.930% P0. 005); (2) IVIG had no relation with inflammatory index, cerebrospinal fluid abnormality and immunosuppression, (3) 95%CI (0 15%) and 99%CI (0 20%) caused by other enterovirus infection. 95%CI (14.87%) and 99%CI (42.79%) caused by Ev71/Cox16 infection. Conclusion the curative effect of IVIG is related to pathogenic bacteria. The effect of IVIG in children with severe hand, foot and mouth disease caused by enterovirus infection other than Ev71/Cox16 is better.
【作者单位】： 吉林大学第一医院药学部;
【分类号】：R725.1
【相似文献】
相关期刊论文 前1条
1 陈杰;武玲;;手足口病患儿外周血T淋巴细胞亚群及免疫球蛋白水平检测结果分析[J];检验医学与临床;2014年10期
相关博士学位论文 前1条
1 宋风霞;迷走神经通过α 7nAChR介导的免疫负调节在重症EV71感染中的作用探讨[D];北京协和医学院;2017年
相关硕士学位论文 前2条
1 何红芳;TLR3基因多态性与儿童肠道病毒71型感染的相关性研究[D];青岛大学;2017年
2 迟彩霞;肠道病毒71型感染致儿童中枢神经系统损害相关因素分析[D];青岛大学;2017年
，本文编号：2316152
本文链接：https://www.wllwen.com/yixuelunwen/eklw/2316152.html
最近更新
教材专著
