结核性脑膜炎患儿生化及脑脊液检测结果与预后的相关性研究

发布时间：2018-11-09 14:52

【摘要】：目的探讨结核性脑膜炎(TBM)患儿生化指标及脑脊液(CSF)检测结果和病情预后的相关性分析,旨在为临床TBM的预后评估提供有效的检查方案。方法选择2006年6月-2015年6月医院儿科及感染科接诊的TBM患儿182例,按照病情预后的不同分为预后良好组93例和预后不良组89例,观察两组患儿干预前实验室生化指标检测与CSF细胞学检测数值差异,分析TBM预后相关影响因素。结果预后良好组中性粒细胞、淋巴细胞、单核细胞表达均明显低于预后不良组,差异有统计学意义(P0.05);预后良好组血浆生化指标肌酐(Cre)、总胆红素(TBIL)、尿素氮(BUN)表达水平与预后不良组比较差异无统计学意义,白蛋白(ALB)、总蛋白(TP)、谷草转氨酶(AST)、谷丙转氨酶(ALT)的表达均显著低于预后不良组,差异有统计学意义(P0.05);logistic回归分析,TBM患儿预后与TP、AST、ALT有密切相关性(P0.05)。结论血浆生化检验对TBM患儿的预后结果具有一定诊断意义,可初步认定,血浆生化检验可用于TBM疾病的诊断与预后评估,关于其临床实用性需进一步以大样本实验进行验证。
[Abstract]:Objective to investigate the correlation between biochemical indexes, cerebrospinal fluid (CSF) (CSF) and prognosis in children with tuberculous meningitis (TBM), so as to provide an effective method for evaluating the prognosis of TBM. Methods from June 2006 to June 2015, 182 patients with TBM were divided into good prognosis group (93 cases) and poor prognosis group (89 cases). To observe the difference of laboratory biochemical index and CSF cytology between the two groups before intervention, and to analyze the prognostic factors related to TBM. Results the expression of neutrophils, lymphocytes and monocytes in the group with good prognosis was significantly lower than that in the group with poor prognosis (P0.05). There was no significant difference in plasma biochemical index, creatinine, total bilirubin, (TBIL), urea nitrogen (BUN) expression between patients with good prognosis and poor prognosis group. Albumin (ALB), total protein (TP), glutamic oxaloacetic transaminase (AST), The expression of glutamate-pyruvic transaminase (ALT) was significantly lower than that of poor prognosis group (P0.05). Logistic regression analysis showed that the prognosis of children with TBM was closely related to TP,AST,ALT (P0.05). Conclusion Plasma biochemistry test has certain diagnostic significance for the prognosis of children with TBM. It can be preliminarily concluded that plasma biochemical test can be used in the diagnosis and prognosis evaluation of TBM diseases, and its clinical practicability needs to be further verified by large sample experiments.
【作者单位】：南阳市第一人民医院儿科;
【分类号】：R529.3

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