特应性体质对毛细支气管炎患儿血清糖皮质激素受体水平的影响

发布时间：2018-11-10 18:05

【摘要】：目的探讨特应性体质(简称特应质)对毛细支气管炎(简称毛支)患儿糖皮质激素受体(GR)表达的影响。方法采用ELISA法测定和比较毛支组(77例,包括34例特应质患儿)和肺炎组(68例)患儿血清中GRα、GRβ水平的变化。38例同期住院的非感染性小儿外科术前患儿,且无特应性及过敏性疾病家族史的患儿作为对照组。结果与对照组比较,毛支组和肺炎组中血清GRα、GRβ水平均明显升高(P0.01);毛支组血清GRα、GRβ水平高于肺炎组(P0.01)。毛支组GRα/GRβ比值较对照组和肺炎组明显升高(P0.01)。毛支组特应质和非特应质患儿血清GRα、GRβ水平与对照组比较均明显升高(P0.01);毛支组非特应质患儿GRβ水平明显高于特应质患儿(P0.01);毛支组特应质患儿GRα/GRβ比值较对照组和毛支组非特应质患儿明显升高(P0.01)。结论毛支患儿血清GRα、GRβ表达水平增强;特应质毛支患儿表现为GRα/GRβ比值增加,提示特应质毛支患儿对糖皮质激素有较高的敏感性。
[Abstract]:Objective to investigate the effect of atopic constitution on glucocorticoid receptor (GR) expression in children with bronchiolitis. Methods the serum levels of GR 伪 and GR 尾 were measured and compared by ELISA in 77 cases (including 34 cases of atopic children) and 68 cases of pneumonia group. Children with no family history of atopic and allergic diseases were used as control group. Results compared with the control group, the serum levels of GR 伪 and GR 尾 in the hair branch group and pneumonia group were significantly increased (P0.01), and the serum GR 伪 and GR 尾 levels in the hair branch group were higher than those in the pneumonia group (P0.01). The ratio of GR 伪 / GR 尾 in hair branch group was significantly higher than that in control group and pneumonia group (P0.01). The serum levels of GR 伪 and GR 尾 in the hair branch group were significantly higher than those in the control group (P0.01), and the GR 尾 levels in the hair branch group were significantly higher than those in the atopic group (P0.01). The ratio of GR 伪 / GR 尾 in the hair branch group was significantly higher than that in the control group and the hair branch group (P0.01). Conclusion the expression of GR 伪 and GR 尾 in serum of children with hair branch is increased, and the ratio of GR 伪 / GR 尾 is increased in children with atopic hair branch, which indicates that the children with hair branch of atopic hair have high sensitivity to glucocorticoid.
【作者单位】：绍兴市人民医院/浙江大学绍兴医院儿内科;
【基金】：浙江省医药卫生一般研究计划A类(2015KYA219)
【分类号】：R725.6

【相似文献】