非免疫性胎儿水肿10例临床分析
发布时间：2018-11-18 13:48
【摘要】：目的探讨非免疫性胎儿水肿(NIHF)的临床特点、诊断及治疗。方法回顾分析2011年1月—2016年12月新生儿重症监护病房中10例诊断NIHF新生儿的临床资料,并复习相关文献。结果 10例NIHF中,男6例、女4例,出生胎龄32~42周,出生体质量2.25~3.95 kg。其中感染性疾病3例(巨细胞病毒、无乳链球菌、微小病毒感染各1例),胎儿心血管异常2例,染色体异常2例,胸腔结构异常1例,双胎输血综合征1例,病因不明1例;临床表现为2处及以上水肿(或积液)8例,仅皮肤水肿2例。最终治愈出院6例,自动出院2例,死亡2例。结论产前超声是诊断NIHF的可靠方法。孕早期胎儿水肿,尤其伴有先天畸形建议终止妊娠。出生后的NIHF应及时诊治,以避免或减少严重并发症。
[Abstract]:Objective to investigate the clinical features, diagnosis and treatment of non-immune fetal edema (NIHF). Methods the clinical data of 10 neonates diagnosed with NIHF in neonatal intensive care unit from January 2011 to December 2016 were retrospectively analyzed and the related literatures were reviewed. Results among the 10 cases of NIHF, 6 cases were male and 4 cases female. The gestational age was 32 ~ 42 weeks, and the birth weight was 2.25 ~ 3.95 kg.. There were 3 cases of infectious diseases (1 case of cytomegalovirus, 1 case of streptococcus lactococcus and 1 case of parvovirus infection), 2 cases of fetal cardiovascular abnormalities, 2 cases of chromosomal abnormalities, 1 case of abnormal thoracic structure, 1 case of twin transfusion syndrome and 1 case of unknown etiology. The clinical manifestations were 2 or more edema (or effusion) in 8 cases, and only 2 cases of skin edema. Finally, 6 cases were cured, 2 cases were discharged automatically and 2 cases died. Conclusion Prenatal ultrasound is a reliable method for the diagnosis of NIHF. Fetal edema in early pregnancy, especially with congenital malformations, is recommended for termination of pregnancy. Postnatal NIHF should be treated in time to avoid or reduce severe complications.
【作者单位】： 上海市儿童医院上海交通大学附属儿童医院新生儿科;
【分类号】：R722.1
本文编号：2340201
[Abstract]:Objective to investigate the clinical features, diagnosis and treatment of non-immune fetal edema (NIHF). Methods the clinical data of 10 neonates diagnosed with NIHF in neonatal intensive care unit from January 2011 to December 2016 were retrospectively analyzed and the related literatures were reviewed. Results among the 10 cases of NIHF, 6 cases were male and 4 cases female. The gestational age was 32 ~ 42 weeks, and the birth weight was 2.25 ~ 3.95 kg.. There were 3 cases of infectious diseases (1 case of cytomegalovirus, 1 case of streptococcus lactococcus and 1 case of parvovirus infection), 2 cases of fetal cardiovascular abnormalities, 2 cases of chromosomal abnormalities, 1 case of abnormal thoracic structure, 1 case of twin transfusion syndrome and 1 case of unknown etiology. The clinical manifestations were 2 or more edema (or effusion) in 8 cases, and only 2 cases of skin edema. Finally, 6 cases were cured, 2 cases were discharged automatically and 2 cases died. Conclusion Prenatal ultrasound is a reliable method for the diagnosis of NIHF. Fetal edema in early pregnancy, especially with congenital malformations, is recommended for termination of pregnancy. Postnatal NIHF should be treated in time to avoid or reduce severe complications.
【作者单位】： 上海市儿童医院上海交通大学附属儿童医院新生儿科;
【分类号】：R722.1
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1 谭岩;;不易诊断的自发性水肿[J];国外医学情报;1984年03期
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