影响早产儿贫血程度的围产期相关因素分析
发布时间：2018-11-18 17:43
【摘要】：目的：贫血是早产儿新生儿期常见现象，贫血程度不同其治疗方法及预后也有差别，重度贫血不仅影响早产儿生长发育，甚至可危及生命。本文拟探讨围产期影响早产儿贫血程度的危险因素以及防治措施。 方法：收集重庆医科大学附属儿童医院2010年1月至2010年12月期间于生后24小时内收入新生儿病房并在住院期间出现新生儿贫血的早产儿136例，按贫血程度分为轻-中度贫血组（n=87）和重度贫血组（n=49），通过单因素检验和Logistic回归对早产儿贫血程度的相关因素分析。 结果：单因素检验，，重度贫血组胎龄、出生体重、出生时的血红蛋白量明显低于轻-中度贫血组，分别为31.71±2.19周vs32.76±2.13周,1657.45±433.36g vs1885.32±485.33g，148.35±19.26g/Lvs161.22±20.8g/L，差异均有统计学意义（P＜0.05）。重度贫血组采血量、住院时间高于轻-中度贫血组，分别为12.28±4ml/Kg vs10.05±3.34ml/Kg,30.8±16.62天vs21.43±11.81天。差异也具有显著统计学意义（P＜0.05）。多因素Logistic回归分析，与采血量＜7ml/Kg组相比，采血量7～13ml/Kg组OR值是1.575（95%CI:0.572～4.707），但差异无统计学意义，采血量＞13ml/Kg与采血量＜7ml/Kg组比较OR值为5.146（95%CI:1.35519～19.542）,差异有统计学意义(P＜0.05)；分析显示住院时间也是早产儿发生重度贫血的危险因素，OR值为1.029；出生时血红蛋白量是早产儿重度贫血的保护因素，OR值为0.962。 结论：早产儿贫血程度与胎龄、出生体重、出生时血红蛋白量、住院时间以及采血量有关。其中出生后2周内的采血量和住院时间是早产儿发生重度贫血的独立危险因素，采血量＞13ml/Kg发生重度贫血的危险性是采血量＜7ml/Kg的5倍左右。适当增加早产儿出生时血红蛋白量，尽量减少医源性失血，缩短住院时间可有效预防早产儿重度贫血的发生。
[Abstract]:Objective: anemia is a common phenomenon in newborns with different degrees of anemia and its treatment and prognosis are also different. Severe anemia not only affects the growth and development of premature infants, but also endangers life. This article aims to explore the perinatal risk factors affecting the anemia degree of preterm infants and the prevention and treatment measures. Methods: from January 2010 to December 2010, 136 premature infants who were admitted to the neonatal ward within 24 hours after birth and developed neonatal anemia during the period of hospitalization in the affiliated Children's Hospital of Chongqing Medical University were collected. According to the degree of anemia, the patients were divided into mild to moderate anemia group and severe anemia group. Univariate test and Logistic regression were used to analyze the related factors of anemia degree in preterm infants. Results: univariate test showed that the gestational age, birth weight and hemoglobin at birth in severe anemia group were significantly lower than those in mild to moderate anemia group (31.71 卤2.19 weeks vs32.76 卤2.13 weeks, 1657.45 卤433.36 g vs1885.32 卤485.33 g, respectively). 148.35 卤19.26g/Lvs161.22 卤20.8 g / L, the difference was statistically significant (P < 0. 05). The amount of blood collected in severe anemia group was higher than that in mild to moderate anemia group (12.28 卤3.34ml / kg 卤30.8 卤16.62 vs21.43 卤11.81 days, respectively). The difference was also statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that the OR value of 7~13ml/Kg group was 1.575 (95%CI:0.572~4.707), but the difference was not statistically significant. The OR value was 5.146 (95%CI:1.35519~19.542) in the group of blood collection > 13ml/Kg and < 7ml/Kg (P < 0. 05). The results showed that the length of hospitalization was also the risk factor of severe anemia in premature infants, the OR value was 1.029, and the hemoglobin content at birth was the protective factor of severe anemia in premature infants, and the OR value was 0.962. Conclusion: the degree of anemia in preterm infants is related to gestational age, birth weight, hemoglobin at birth, length of hospitalization and blood collection. The blood intake and hospital stay within 2 weeks after birth were the independent risk factors for severe anemia in premature infants. The risk of severe anemia in premature infants was higher than that in 13ml/Kg, which was 5 times higher than that in 7ml/Kg. Increasing the amount of hemoglobin at birth, reducing iatrogenic blood loss and shortening the hospital stay can effectively prevent severe anemia in preterm infants.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R722.6
本文编号：2340695
[Abstract]:Objective: anemia is a common phenomenon in newborns with different degrees of anemia and its treatment and prognosis are also different. Severe anemia not only affects the growth and development of premature infants, but also endangers life. This article aims to explore the perinatal risk factors affecting the anemia degree of preterm infants and the prevention and treatment measures. Methods: from January 2010 to December 2010, 136 premature infants who were admitted to the neonatal ward within 24 hours after birth and developed neonatal anemia during the period of hospitalization in the affiliated Children's Hospital of Chongqing Medical University were collected. According to the degree of anemia, the patients were divided into mild to moderate anemia group and severe anemia group. Univariate test and Logistic regression were used to analyze the related factors of anemia degree in preterm infants. Results: univariate test showed that the gestational age, birth weight and hemoglobin at birth in severe anemia group were significantly lower than those in mild to moderate anemia group (31.71 卤2.19 weeks vs32.76 卤2.13 weeks, 1657.45 卤433.36 g vs1885.32 卤485.33 g, respectively). 148.35 卤19.26g/Lvs161.22 卤20.8 g / L, the difference was statistically significant (P < 0. 05). The amount of blood collected in severe anemia group was higher than that in mild to moderate anemia group (12.28 卤3.34ml / kg 卤30.8 卤16.62 vs21.43 卤11.81 days, respectively). The difference was also statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that the OR value of 7~13ml/Kg group was 1.575 (95%CI:0.572~4.707), but the difference was not statistically significant. The OR value was 5.146 (95%CI:1.35519~19.542) in the group of blood collection > 13ml/Kg and < 7ml/Kg (P < 0. 05). The results showed that the length of hospitalization was also the risk factor of severe anemia in premature infants, the OR value was 1.029, and the hemoglobin content at birth was the protective factor of severe anemia in premature infants, and the OR value was 0.962. Conclusion: the degree of anemia in preterm infants is related to gestational age, birth weight, hemoglobin at birth, length of hospitalization and blood collection. The blood intake and hospital stay within 2 weeks after birth were the independent risk factors for severe anemia in premature infants. The risk of severe anemia in premature infants was higher than that in 13ml/Kg, which was 5 times higher than that in 7ml/Kg. Increasing the amount of hemoglobin at birth, reducing iatrogenic blood loss and shortening the hospital stay can effectively prevent severe anemia in preterm infants.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R722.6
【参考文献】
相关期刊论文 前5条
1 彭华;童笑梅;;早产儿贫血的相关因素分析[J];中国当代儿科杂志;2008年05期
2 丁璐;吴本清;黄进洁;刘智屏;陈丽;;促红细胞生成素对新生大鼠高氧肺损伤细胞凋亡的影响[J];中国当代儿科杂志;2010年07期
3 李潞露;韦红;;促红细胞生成素在新生儿相关疾病中的研究进展[J];中国当代儿科杂志;2011年12期
4 陈晓文,吕回,王卫,张吉吉;影响早产儿贫血的因素[J];实用儿科临床杂志;2001年04期
5 甄子俊;胎龄与新生儿贫血的关系探讨[J];中国优生与遗传杂志;2001年03期
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