不同年龄组儿童噬血细胞综合征的临床特点及预后研究
发布时间：2018-11-21 14:17
【摘要】：目的探讨不同年龄组儿童噬血细胞综合征(HPS)的临床特点与预后因素分析。方法将85例HPS患儿按年龄分为0~2岁(A组)、2~8岁(B组)和8~14岁(C组),从病因、病理、临床症状、实验室检查及预后等方面进行回顾性分析。结果 A、B和C组病因均以EB病毒感染为主,感染阳性率C组明显高于A、B组;骨髓检查粒细胞红细胞比例(粒红比)小于1.0的发生率,A组高于C组;颈部淋巴结肿大发生在B组中多见,肝脾肿大在C组中最少见;浆膜腔积液发生在B组多见;实验室检查乳酸脱氢酶(LDH)B组高于A组,以上差异均有统计学意义(P0.05)。其他临床症状和实验室检查结果在组之间差异无统计学意义(P0.05)。存活与死亡患儿比较,浆膜腔积液、三酰甘油(TG)、CD4/CD8及骨髓检查粒红比比较,差异有统计学意义(P0.05),将上述因素进行Logistic分析,显示TG3.5mmol/L、CD4/CD81.24、骨髓粒红比小于1.02是影响儿童HPS预后的危险因素(P0.05)。结论儿童HPS有部分临床特点与发病年龄有关,TG、CD4/CD8及骨髓粒红比水平是影响预后的危险因素。
[Abstract]:Objective to investigate the clinical features and prognostic factors of hemophagocytic syndrome (HPS) in children of different ages. Methods Eighty-five children with HPS were divided into 3 groups according to their age: group A, group B, and group C. The etiology, pathology, clinical symptoms, laboratory examination and prognosis were analyzed retrospectively. Results EB virus infection was the main etiology in group A and C, the positive rate of infection in group C was significantly higher than that in group A, and the incidence of granulocyte ratio in group A was higher than that in group C when the ratio of granulocyte to erythrocyte in bone marrow examination was less than 1.0. Cervical lymphadenopathy was more common in group B, hepatosplenomegaly was the most rare in group C, serous cavity effusion occurred in group B. Laboratory examination of lactate dehydrogenase (LDH) B group was higher than group A, the above differences were statistically significant (P0.05). There was no significant difference between the two groups in other clinical symptoms and laboratory results (P0.05). There were significant differences between survival and death, serous cavity effusion, triglyceride (TG), CD4/CD8 and granulocyte ratio in bone marrow examination (P0.05). The above factors were analyzed by Logistic to show TG3.5mmol/L,CD4/CD81.24,. Bone marrow granulocyte ratio less than 1.02 was a risk factor for the prognosis of HPS in children (P0.05). Conclusion some clinical features of HPS in children are related to age of onset. TG,CD4/CD8 and bone marrow granulocyte ratio are risk factors for prognosis.
【作者单位】： 成都市妇女儿童中心医院血液肿瘤科;
【分类号】：R725.5
，
本文编号：2347218
[Abstract]:Objective to investigate the clinical features and prognostic factors of hemophagocytic syndrome (HPS) in children of different ages. Methods Eighty-five children with HPS were divided into 3 groups according to their age: group A, group B, and group C. The etiology, pathology, clinical symptoms, laboratory examination and prognosis were analyzed retrospectively. Results EB virus infection was the main etiology in group A and C, the positive rate of infection in group C was significantly higher than that in group A, and the incidence of granulocyte ratio in group A was higher than that in group C when the ratio of granulocyte to erythrocyte in bone marrow examination was less than 1.0. Cervical lymphadenopathy was more common in group B, hepatosplenomegaly was the most rare in group C, serous cavity effusion occurred in group B. Laboratory examination of lactate dehydrogenase (LDH) B group was higher than group A, the above differences were statistically significant (P0.05). There was no significant difference between the two groups in other clinical symptoms and laboratory results (P0.05). There were significant differences between survival and death, serous cavity effusion, triglyceride (TG), CD4/CD8 and granulocyte ratio in bone marrow examination (P0.05). The above factors were analyzed by Logistic to show TG3.5mmol/L,CD4/CD81.24,. Bone marrow granulocyte ratio less than 1.02 was a risk factor for the prognosis of HPS in children (P0.05). Conclusion some clinical features of HPS in children are related to age of onset. TG,CD4/CD8 and bone marrow granulocyte ratio are risk factors for prognosis.
【作者单位】： 成都市妇女儿童中心医院血液肿瘤科;
【分类号】：R725.5
，
本文编号：2347218
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