口服普萘洛尔治疗婴幼儿血管瘤的临床观察

发布时间：2018-12-10 14:28

【摘要】：目的:评价普萘洛尔治疗婴幼儿血管瘤的安全性和临床疗效。方法:2010年9月至2013年3月,我科对44例血管瘤患儿予口服普萘洛尔,治疗前行心电图、超声心动图、血常规、肝功能、心肌酶谱等检查进行评估。服药剂量为第1天1.0 mg·kg-1,第2天1.5 mg·kg-1,第3天2 mg·kg-1,分2次服用,每12 h服药1次。住院治疗期间严密监测心率、血压、呼吸情况变化,无异常表现者住院1周出院,并每月复诊,治疗结束时逐渐减量至停药。对服药后1周、1个月和停药时疗效分别作评价。患者平均随访时间为12.3个月(9.2~20.3个月)。结果:所有患儿在口服普萘洛尔1周后血管瘤瘤体生长受到抑制,服药1个月和停药时95.5%(42/44)的患儿表现为瘤体缩小。4例伴发溃疡的血管瘤患儿在服药后1个月内溃疡均愈合。用药期间6.8%(3/44)患儿出现腹泻、食欲减退,22.7%(10/44)患儿停药后有复发倾向。结论:普萘洛尔治疗婴幼儿血管瘤疗效明显,不良反应小,可作为严重婴幼儿血管瘤的一线治疗。
[Abstract]:Objective: to evaluate the safety and clinical effect of propranolol in the treatment of infantile hemangioma. Methods: from September 2010 to March 2013, 44 children with hemangioma were treated with propranolol. Electrocardiogram, echocardiography, blood routine, liver function and myocardial enzyme spectrum were evaluated before treatment. The dosage was 1.0 mg kg-1, on the first day, 1.5 mg kg-1, on the second day, 2 mg kg-1, on the third day, once every 12 hours. The changes of heart rate, blood pressure and respiration were closely monitored during hospitalization. The patients with no abnormal symptoms were hospitalized for one week and discharged from hospital, and returned to hospital every month. At the end of the treatment, the patients gradually reduced to the end of the treatment. The therapeutic effects were evaluated 1 week, 1 month and 1 month after treatment. The mean follow-up time was 12.3 months (9.2 卤20.3 months). Results: the tumor growth of hemangioma was inhibited in all children after oral propranolol for 1 week. 95. 5% (42 / 44) of the children with hemangioma with ulcers healed within 1 month after taking the drug and stopped taking the drug, and 4 cases of hemangioma with ulcers were healed within 1 month after taking the medicine (42 / 44). Diarrhea and anorexia occurred in 6.8% (3 / 44) of the children during the treatment period, and 22. 7% (10 / 44) of the children had a tendency to recur after withdrawal. Conclusion: propranolol is effective in the treatment of infantile hemangioma.
【作者单位】：盐城市第一人民医院烧伤整形科;
【分类号】：R732.2

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