黄芪注射液对急性淋巴细胞白血病患儿感染因素的影响

发布时间：2018-12-15 22:45

【摘要】：目的：探讨黄芪注射液对急性淋巴细胞白血病(ALL)诱导缓解化疗期间患儿感染相关因素的影响。方法：采用随机双盲法将91例ALL患儿分为治疗组(47例)和对照组(44例),治疗组在诱导缓解化疗的同时给予加用黄芪注射液0.5mL／kg.d,共35d,对照组给予同等剂量生理盐水代替,两组其他支持治疗相同,比较两组诱导缓解化疗结束后患儿感染的发生率、感染持续时间、白细胞及中性粒细胞水平、感染部位及分泌物病原菌培养阳性率等。结果：治疗组47例患儿中有4例出现过敏反应后退出实验,研究显示诱导缓解化疗后治疗组患儿的感染发生率均低于对照组(均P0.05)；不同感染部位的感染持续时间均低于对照组(均P0.05)；治疗组中性粒细胞水平均高于对照组(均P0.05)；治疗组呼吸道感染、泌尿道感染、血液感染及皮肤软组织感染发生率均低于对照组(均P0.05)；感染病原菌以革兰阴性菌为主,感染患儿中治疗组分泌物培养阳性率低于对照组(P0.05)。结论：黄芪注射液可能在诱导缓解化疗期间减轻了化疗药物对骨髓的抑制,也可能通过提高中性粒细胞水平,从而使ALL患儿在诱导缓解化疗期间感染发生率降低,感染发生时持续时间缩短。
[Abstract]:Objective: to investigate the effect of astragalus injection on the infection related factors in children with acute lymphoblastic leukemia (ALL) induced chemotherapy. Methods: 91 children with ALL were randomly divided into treatment group (47 cases) and control group (44 cases). The control group was given the same dose of saline instead of other supportive therapy. The incidence of infection, duration of infection, leukocyte and neutrophil levels were compared between the two groups after induction and remission chemotherapy. The positive rate of pathogenic bacteria culture in infection sites and secretions, etc. Results: 4 of 47 children in the treatment group had allergic reaction and withdrew from the experiment. The incidence of infection in the treatment group after induced remission chemotherapy was lower than that in the control group (P0.05). The duration of infection in different infection sites was lower than that in control group (P0.05), and the level of neutrophil in treatment group was higher than that in control group (P0.05). The incidence of respiratory tract infection, urinary tract infection, blood infection and skin soft tissue infection in the treatment group were lower than those in the control group (P0.05). Gram-negative bacteria were the main pathogens of infection, and the positive rate of secretion culture in the treatment group was lower than that in the control group (P0.05). Conclusion: Astragalus injection may reduce the inhibition of bone marrow induced by chemotherapeutic agents or increase the level of neutrophils during the induction and remission of chemotherapy, so that the incidence of infection in children with ALL may be reduced during the induction and remission of chemotherapy. The duration of infection was shortened.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R733.7

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