重症监护病房患儿万古霉素血药浓度的监测
发布时间：2018-12-16 00:03
【摘要】：目的分析万古霉素不同给药次数与重症监护病房(PICU)患儿血药浓度的关系,不同谷浓度与疗效的关系,以及药物不良反应。方法回顾2013年1月—2016年6月入住PICU并使用万古霉素的72例患儿的临床资料,其中58例万古霉素剂量为40 mg/(kg·d),14例60 mg/(kg·d);剂量40 mg/(kg·d)的患儿中q12h给药19例,q8h给药22例,q6h给药17例;万古霉素给药至少4个剂量后,在给药前30 min内采集血标本检测谷浓度;给药结束后30~60 min内采集血标本检测峰浓度;以高效液相色谱(HPLC)法快速测定血浆万古霉素浓度。结果万古霉素以40 mg/(kg·d)进行治疗时,q12h、q 8 h和q 6 h三组之间万古霉素谷浓度与峰浓度的差异均无统计学意义(P0.05)。万古霉素谷浓度≤5μg/m L和5μg/m L组之间显效及有效率差异无统计学意义(81.8%对84.0%,P0.05)。与万古霉素40 mg/(kg·d)组(q 8 h)比较,60 mg/(kg·d)组谷浓度与峰浓度均明显升高,差异有统计学意义(P0.05)。结论使用常规剂量的万古霉素谷浓度难以达到10μg/m L;为达到有效治疗浓度,降低不良反应,可增加万古霉素剂量,增加给药次数。
[Abstract]:Objective to analyze the relationship between different times of vancomycin administration and serum concentration of vancomycin in (PICU) children, the relationship between different concentrations of vancomycin and curative effect, and adverse drug reactions. Methods the clinical data of 72 children admitted to PICU from January 2013 to June 2016 with vancomycin were retrospectively reviewed, of which 58 cases were treated with vancomycin (40 mg/ (kg d),) and 14 cases (60 mg/ (kg d);) with vancomycin. In the 40 mg/ (kg d) group, 19 cases were given q12h, 22 cases Q8h, 17 cases Q6h, and at least 4 doses of vancomycin, the blood samples were collected 30 min before the administration of vancomycin to detect the grain concentration. The peak concentration of plasma vancomycin was determined by high performance liquid chromatography (HPLC), and the plasma vancomycin concentration was determined by high performance liquid chromatography (HPLC). Results when vancomycin was treated for 40 mg/ (kg d), there was no significant difference in the concentration and peak concentration of vancomycin between the three groups (P0.05). There was no significant difference in efficacy and effective rate between groups of vancomycin concentration 鈮，
本文编号：2381510
[Abstract]:Objective to analyze the relationship between different times of vancomycin administration and serum concentration of vancomycin in (PICU) children, the relationship between different concentrations of vancomycin and curative effect, and adverse drug reactions. Methods the clinical data of 72 children admitted to PICU from January 2013 to June 2016 with vancomycin were retrospectively reviewed, of which 58 cases were treated with vancomycin (40 mg/ (kg d),) and 14 cases (60 mg/ (kg d);) with vancomycin. In the 40 mg/ (kg d) group, 19 cases were given q12h, 22 cases Q8h, 17 cases Q6h, and at least 4 doses of vancomycin, the blood samples were collected 30 min before the administration of vancomycin to detect the grain concentration. The peak concentration of plasma vancomycin was determined by high performance liquid chromatography (HPLC), and the plasma vancomycin concentration was determined by high performance liquid chromatography (HPLC). Results when vancomycin was treated for 40 mg/ (kg d), there was no significant difference in the concentration and peak concentration of vancomycin between the three groups (P0.05). There was no significant difference in efficacy and effective rate between groups of vancomycin concentration 鈮，
本文编号：2381510
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