低聚半乳糖对早产大鼠肠道菌群的调节作用

发布时间：2018-12-17 12:47

【摘要】：目的探讨低聚半乳糖(GOS)对早产大鼠肠道菌群的调节作用。方法早产新生大鼠分为GOS组和对照组,GOS组每天滴管喂养GOS 4g/kg,共14d。于喂养GOS后7d和14d,观察大鼠一般情况并称质量,同时取大鼠直肠末端粪便,行双歧杆菌、乳酸杆菌、肠杆菌及肠球菌培养并行菌落计数。结果 GOS组与对照组在给药期间均正常生长,精神状态等未见异常。与对照组比较,GOS组体质量增长差异无统计学意义(P0.05),使用GOS 7d时,双歧杆菌、乳酸杆菌、肠杆菌及肠球菌与同时间点对照组比较,差异无统计学意义(P0.05)。使用GOS 14d后,大鼠粪便中双歧杆菌、乳酸杆菌较对照组明显增加,而肠杆菌、肠球菌明显减少,差异均有统计学意义(P0.05)。结论低聚半乳糖可促进早产鼠双歧杆菌和乳酸杆菌增长,抑制肠杆菌及肠球菌生长,从而调节肠道菌群平衡。
[Abstract]:Objective to investigate the effect of galactose oligosaccharide (GOS) on intestinal flora of preterm rats. Methods premature newborn rats were divided into GOS group and control group. GOS group was fed with GOS 4 g / kg daily for 14 days. At the 7th and 14th days after GOS feeding, the general condition of the rats was observed and weighed. The feces at the end of rectum of the rats were collected and counted with the culture of Bifidobacterium, Lactobacillus, Enterobacter and Enterococcus. Results both GOS group and control group had normal growth and no abnormal mental state. Compared with the control group, there was no significant difference in body mass growth between GOS group and control group (P0.05). When GOS was used for 7 days, there was no significant difference in Bifidobacterium, Lactobacillus, Enterobacterium and Enterococcus compared with the control group at the same time point (P0.05). After using GOS for 14 days, the number of bifidobacterium and Lactobacillus in feces of rats was significantly higher than that of control group, while Enterobacter and Enterococcus decreased significantly (P0.05). Conclusion Polygalactose can promote the growth of bifidobacterium and lactobacillus in preterm mice, inhibit the growth of Enterobacter and Enterococcus, and regulate the balance of intestinal flora.
【作者单位】：江苏大学附属医院儿科;
【基金】：江苏省临床医学专项基金(BL2012058) 江苏大学临床医学专项基金(JDLCZX004)
【分类号】：R722.6

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