热毒宁注射液辅助治疗小儿轮状病毒肠炎及对血清炎症因子水平的影响

发布时间：2019-01-03 10:43

【摘要】：目的:探讨热毒宁注射液辅助治疗小儿轮状病毒肠炎的临床疗效及对血清炎症因子水平的影响。方法:使用随机数字表法,将贵州省黔东南州人民医院收治的110例小儿轮状病毒肠炎患者分为2组(n=55),对照组患儿实施常规西医治疗并应用利巴韦林,观察组患儿在对照组基础上加用热毒宁注射液,观察两组患儿治疗前后的临床症状、心肌酶谱、血清炎症因子水平的变化。结果:观察组患儿的治疗总有效率为92.73%,显著高于对照组的80.00%(P0.05);观察组患儿的止泻时间、退热时间、止吐时间、轮状病毒转阴时间、住院时间均显著短于对照组(P0.05)。治疗后两组患儿IL-6、TNF-α、CRP水平均较治疗前显著降低,且观察组治疗后IL-6、TNF-α、CRP水平均显著低于对照组(P0.05)。观察组治疗3、7天粪便中轮状病毒的转阴率均显著高于对照组(P0.05)。观察组治疗后CK-MB、CK、LDH水平均显著低于对照组(P0.05)。结论:在小儿轮状病毒肠炎的临床治疗中辅助应用热毒宁注射液,能有效降低血清炎症因子水平,加快症状消退,提高治疗效果。
[Abstract]:Objective: to investigate the clinical effect of Reduning injection in the treatment of rotavirus enteritis in children and its effect on serum inflammatory factor level. Methods: 110 children with rotavirus enteritis in Qiandongnan people's Hospital of Guizhou Province were randomly divided into two groups (n = 55). The control group was treated with routine western medicine and ribavirin. The clinical symptoms, myocardial enzyme spectrum and serum inflammatory factor levels were observed before and after treatment. Results: the total effective rate of treatment in the observation group was 92.73, which was significantly higher than that in the control group (80.00%) (P0.05). The time of stopping diarrhea, antipyretic time, stopping vomiting time, rotavirus turning negative time, hospitalization time of the observation group were significantly shorter than those of the control group (P0.05). After treatment, the levels of IL-6,TNF- 伪 and CRP in the two groups were significantly lower than those before treatment, and the levels of IL-6,TNF- 伪 and CRP in the observation group were significantly lower than those in the control group (P0.05). The seroconversion rate of rotavirus in feces of the observation group was significantly higher than that of the control group on the 7th day after treatment (P0.05). After treatment, CK-MB,CK,LDH levels in the observation group were significantly lower than those in the control group (P0.05). Conclusion: in the clinical treatment of rotavirus enteritis in children, the application of Reduning injection can effectively reduce the level of serum inflammatory factors, accelerate the regression of symptoms and improve the therapeutic effect.
【作者单位】：贵州省黔东南州人民医院儿科;
【分类号】：R725.1

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