表皮生长因子与足月新生儿晚发型母乳性黄疸的相关性研究

发布时间：2019-01-11 09:38

【摘要】：目的：①探讨EGF与足月新生儿晚发型母乳性黄疸的关系。②探讨患儿TcB的最佳检测部位。方法：选取我院儿科门诊就诊的晚发型母乳性黄疸患儿75例（实验组），相当日龄的正常新生儿25例（对照组），比较两组新生儿血清及母乳中EGF差异；对30例晚发型母乳性黄疸患儿停母乳72h左右，比较停母乳前后患儿血清胆红素及血清、母乳中EGF差异。采用Elisa方法检测EGF浓度。同时应用JH20-1C经皮黄疸测试仪测患儿额部及胸部TcB，前两者和均值记为额胸部TcB。不同部位TcB值与TSB值进行比较，探讨TcB的最佳检测部位及与TSB值的差异。结果：①实验组TSB值、血清及母乳EGF浓度均高于对照组（分别是233.16±41.93μmol/L VS115.7±33.89μmol/L，， P0.01；556.37±169.5pg/ml VS493.24±159.82pg/ml，P0.05；338.59±99.87pg/ml VS317.92±85.70pg/ml，P0.05）。②30例配对样本停母乳后患儿TSB值、血清中EGF浓度下降，差异具有统计学意义（分别为228.82±41.07μmol/L VS159.05±48.74μmol/L，P0.001，下降约24.8%-36.4%；502.27±188.40pg/ml VS444.81±134.18pg/ml，P0.05）。停母乳前后母乳中EGF浓度变化无统计学意义（343.50±95.23pg/ml VS338.81±104.03pg/ml）。③TcB_额、TcB_(额胸)、TcB_胸与TSB值呈显著正相关性（相关系数分别是r_额=0.815，P0.001；r额胸=0.812，P0.001；r_胸=0.798，P0.001）。④TcB_额、TcB额胸、TcB_胸值平均要高于TSB值约2.13，1.53，0.98mg/dL。胸部是TcB的最佳检测部位。结论：EGF可能与足月新生儿晚发型母乳性黄疸的发生密切相关。胸部可以作为TcB检测最佳部位。TcB较TSB约高1-2mg/dl。在临床应用经皮胆红素诊疗时，要考虑到TcB与TSB之间的差异。
[Abstract]:Objective: to investigate the relationship between EGF and late breast-milk jaundice in term neonates, and to explore the best detection site of TcB in children. Methods: 75 children with late-onset breast milk jaundice (experimental group) and 25 normal newborns (control group) from pediatric outpatient clinic were selected to compare the difference of EGF in serum and breast milk between the two groups. The serum bilirubin and serum and EGF in breast milk of 30 children with late-onset breast milk jaundice were compared before and after stopping breast milk for 72 hours. The concentration of EGF was detected by Elisa method. At the same time, JH20-1C percutaneous jaundice tester was used to measure the frontal part and chest TcB, of children before both and the mean value was recorded as frontothorax TcB.. The TcB value of different parts was compared with the TSB value, and the best detection site of TcB and the difference between TcB and TSB value were discussed. Results: 1the TSB value, serum and EGF concentration of breast milk in the experimental group were higher than those in the control group (233.16 卤41.93 渭 mol/L VS115.7 卤33.89 渭 mol/L, P 0.01), 556.37 卤169.5pg/ml VS493.24 卤159.82 PG / ml, respectively. (338.59 卤99.87pg/ml VS317.92 卤85.70 PG / ml P 0.05). The TSB value and serum EGF concentration of 230 matched children after stopping breast milk decreased significantly (228.82 卤41.07 渭 mol/L VS159.05 卤48.74 渭 mol/L,P0.001, respectively). About 24.8- 36.4cm; 502.27 卤188.40pg/ml VS444.81 卤134.18 PG / ml P 0.05). There was no significant difference in the concentration of EGF between breast milk and breast milk before and after withdrawal (343.50 卤95.23pg/ml VS338.81 卤104.03pg/ml). 3TcBamount, TcB_ (frontothorax), TcB_ chest and TSB value were positively correlated (r _ r = 0.815, r _ 0. 815, r = 0. 815, r = 0. 815). P0.001; R forehead chest = 0.812g P 0.001rthorax = 0.798g P0.001). 4TcBx, TcB forehead chest, TcB_ chest value were higher than TSB value about 2.131.53 ~ 0.98mg / dL on average. The chest is the best detection site for TcB. Conclusion: EGF may be associated with late breast milk jaundice in term neonates. The chest can be used as the best site for TcB detection. TcB is about 1-2 mg / dl. higher than TSB. The difference between TcB and TSB should be taken into account in clinical diagnosis and treatment of percutaneous bilirubin.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R722.1

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