自拟清肺化痰汤治疗小儿肺炎支原体感染后慢性咳嗽（痰热壅肺证）临床疗效观察

发布时间：2019-03-01 14:24

【摘要】：目的:观察自拟清肺化痰汤治疗小儿肺炎支原体感染后慢性咳嗽(痰热壅肺证)的临床疗效。方法:将60例西医诊断为肺炎支原体感染后慢性咳嗽,中医辨病辨证为咳嗽-痰热壅肺证患儿随机分成对照组30人和治疗组30人。对照组予阿奇霉素口服,治疗组予清肺化痰汤剂+阿奇霉素口服。观察疗程为2周,比较两组患儿治疗前后主要证候积分、次要证候积分、总证候积分及总有效率,分析其差异是否具有统计学意义。结果:治疗前,两组患儿的性别、舌质、舌苔、脉象,经卡方检验,P0.05,差异无统计学意义,两组具有可比性;治疗前两组患儿年龄分布、咳嗽、咳痰、咯痰性质、咳时面赤唇红发作次数、咽部充血相关证候,经秩和检验,P0.05,差异无统计学意义,两组具有可比性;治疗前两组患儿主、次要证候积分及总证候积分经两独立样本t检验,P0.05,差异无统计学差异,两组具有可比性。(1)证候积分:治疗后对照组与治疗组主要证候积分,经两独立样本t检验,P0.05,差异具有统计学意义;治疗后对照组与治疗组次要证候积分,经两独立样本t检验,P0.05,差异具有统计学意义;治疗后对照组与治疗组总证候积分,经两独立样本t检验,P0.05,差异具有统计学意义。治疗前后,对照组内部主、次要证候积分及总证候积分,经配对t检验,P0.05,差异具有统计学意义;治疗前后,治疗组内部主、次要证候积分及总证候积分,经配对t检验,P0.05,差异具有统计学意义。(2)总疗效:对照组30例,痊愈3例,显效3例,有效15例,无效9例,对照组总有效率为70.0%;治疗组30例,痊愈7例,显效7例,有效14例,无效2例,治疗组总有效率为93.3%,经秩和检验,P0.05,两组总有效率差异,具有统计学意义,可认为治疗组疗效优于对照组。结论:清肺化痰汤联合阿奇霉素口服治疗小儿肺炎支原体感染后慢性咳嗽,中医属咳嗽-痰热壅肺证具有确切的临床疗效,值得临床推广应用。
[Abstract]:Objective: to observe the clinical effect of self-made Qingfei Huatan decoction on chronic cough (phlegm-heat syndrome) after infection of mycoplasma pneumoniae in children. Methods: 60 cases of chronic cough diagnosed as mycoplasma pneumoniae infection by western medicine were randomly divided into two groups: control group (30 cases) and treatment group (30 cases). The control group was given azithromycin orally, and the treatment group was given azithromycin orally by Qingfei Huatan decoction. The course of treatment was 2 weeks. The main syndrome integral, secondary syndrome score, total syndrome score and total effective rate were compared between the two groups before and after treatment, and the difference between the two groups was statistically significant. Results: before treatment, there was no significant difference in sex, tongue quality, tongue coating, pulse pattern between the two groups by Chi-square test, P 0.05, and there was no significant difference between the two groups. Before treatment, there was no significant difference between the two groups in age distribution, cough, expectoration and expectoration nature, the number of red lip attacks on the face of cough, the syndrome related to pharynx hyperemia, the rank sum test, P0.05, there was no significant difference between the two groups, and the two groups were comparable. Before the treatment, the main and secondary syndrome integral and the total syndrome score of the two groups were tested by two independent samples t test, P 0.05, there was no statistical difference between the two groups. (1) the syndrome integral: after treatment, the main syndrome integral of the control group and the treatment group was the main syndrome integral, and there was no statistical difference between the two groups. By t test of two independent samples, P 0.05, the difference was statistically significant. After treatment, the scores of syndrome between the control group and the treatment group were significantly higher than those of the control group (P 0.05), by two independent samples t-test (P 0.05). After treatment, the total syndrome score between the control group and the treatment group was statistically significant by two independent sample t-test, P 0.05. Before and after treatment, the scores of the main and secondary syndromes and the total syndrome scores in the control group were statistically significant by paired t-test, P 0.05; Before and after treatment, the scores of main and secondary syndromes and total syndrome scores in the treatment group were statistically significant by paired t-test, P 0.05. (2) the total curative effect: 30 cases in the control group, 3 cases cured, 3 cases significantly effective, 15 cases effective, 3 cases in the control group, 3 cases in the control group and 15 cases in the control group. The total effective rate of the control group was 70.0%; In the treatment group, 7 cases were cured, 7 cases were markedly effective, 14 cases were effective, and 2 cases were ineffective. The total effective rate of the treatment group was 93.3%. By rank sum test, P 0.05, the total effective rate of the two groups was significantly different. The therapeutic effect of the treatment group was better than that of the control group. Conclusion: Qingfei Huatan decoction combined with azithromycin is effective in treating chronic cough after infection of Mycoplasma pneumoniae in children. Chinese medicine belongs to cough-phlegm-heat syndrome, which is worthy of clinical popularization and application.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R272

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